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Titolo:
DIAGNOSTIC-VALUE OF AGNOR STAINING IN FOLLICULAR CELL NEOPLASMS OF THE THYROID - COMPARISON OF EVALUATION METHODS AND NUCLEOLAR FEATURES
Autore:
RUSCHOFF J; PRASSER C; CORTEZ T; HOHNE HM; HOHENBERGER W; HOFSTADTER F;
Indirizzi:
UNIV REGENSBURG,INST PATHOL,DEPT PATHOL,FRANZ JOSEF STRAUSS ALLEE 1 W-8400 REGENSBURG GERMANY UNIV REGENSBURG,DEPT SURG W-8400 REGENSBURG GERMANY
Titolo Testata:
The American journal of surgical pathology
fascicolo: 12, volume: 17, anno: 1993,
pagine: 1281 - 1288
SICI:
0147-5185(1993)17:12<1281:DOASIF>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
ORGANIZER REGIONS; CARCINOMA; PROTEINS; LESIONS; TISSUE; BENIGN;
Keywords:
THYROID; NEOPLASM; AGNOR; EVALUATION METHODS; NUCLEOLAR MORPHOMETRY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
J. Ruschoff et al., "DIAGNOSTIC-VALUE OF AGNOR STAINING IN FOLLICULAR CELL NEOPLASMS OF THE THYROID - COMPARISON OF EVALUATION METHODS AND NUCLEOLAR FEATURES", The American journal of surgical pathology, 17(12), 1993, pp. 1281-1288

Abstract

The diagnostic value of argyrophil staining of nucleolar organizer regions (AgNOR) was studied in 95 non-neoplastic and neoplastic follicular lesions of the thyroid. Different AgNOR parameters such as number, size, and distribution pattern were determined using digital image analysis. In addition, nuclear and nucleolar size as well as the percentage of nucleoli touching the nuclear membrane (nucleolar margination) were assessed. A stepwise increase in nuclear size and AgNOR counts from normal thyroid tissue to follicular adenoma as well as from differentiated follicular to anaplastic carcinoma was found (mean nuclear area[mum2]/mean AgNOR number per cell: 21.5/1.6 vs. 34.4/3.5 and 45.3/5.0vs. 66.5/10.8, p < 0.01/p < 0.001). There was, however, no clear separation between these diagnostic groups. In contrast, an almost total discrimination between follicular adenoma and carcinoma was achieved byquantification of AgNORs per tumor cell nucleolus (AgNOR distributionscore). In benign adenomas, 3.3% (range, 0-8.8%) of the cells showed nucleoli with at least five AgNOR dots within one focal plane, whereasin follicular carcinomas, the corresponding value was 34.1% (range, 12-75%). Two of four cases of so-called atypical adenomas showed valuesin the range of benign adenomas, and two were in the range of follicular carcinomas. In comparison with other nuclear and nucleolar parameters, the AgNOR distribution score proved the most valuable diagnostic criterion for the cytomorphological differentiation between follicularadenoma and carcinoma of the thyroid.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 22:13:47