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Titolo:
CHIMERIC NICOTINIC SEROTONERGIC RECEPTOR COMBINES DISTINCT LIGAND-BINDING AND CHANNEL SPECIFICITIES
Autore:
EISELE JL; BERTRAND S; GALZI JL; DEVILLERSTHIERY A; CHANGEUX JP; BERTRAND D;
Indirizzi:
INST PASTEUR,CNRS,UNITE NEUROBIOL MOLEC D1284,25 RUE DR ROUX F-75724 PARIS 15 FRANCE UNIV GENEVA,MED CTR,FAC MED,DEPT PHYSIOL CH-1211 GENEVA 4 SWITZERLAND
Titolo Testata:
Nature
fascicolo: 6454, volume: 366, anno: 1993,
pagine: 479 - 483
SICI:
0028-0836(1993)366:6454<479:CNSRCD>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
GATED ION CHANNEL; MARMORATA ACETYLCHOLINE-RECEPTOR; ALPHA-SUBUNIT; DELTA-SUBUNIT; XENOPUS OOCYTES; 5-HYDROXYTRYPTAMINE; EXPRESSION; SEQUENCES; CALCIUM; NEURONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
J.L. Eisele et al., "CHIMERIC NICOTINIC SEROTONERGIC RECEPTOR COMBINES DISTINCT LIGAND-BINDING AND CHANNEL SPECIFICITIES", Nature, 366(6454), 1993, pp. 479-483

Abstract

THE neuronal nicotinic alpha7 (nAChR) and 5-hydroxytryptamine (5HT3) receptors1-3 are ligand-gated ion channels with a homologous topological organization and have activation and desensitization reactions in common. Yet these homo-oligomeric receptors differ in the pharmacology of their binding sites for agonists and competitive antagonists3,4, and in their sensitivity to Ca2+ ions. The alpha7 channel is highly permeable to Ca2+ ions5,6 and external Ca2+ ions potentiate, in an allosteric manner, the permeability response to acetylcholine, as shown for other neuronal nAChRs7,8. The 5HT3 channel, in contrast, is not permeable to Ca2+ ions, but blocked by them3,9. To assign these properties todelimited domains of the primary structure, we constructed several recombinant chimaeric alpha7-5HT3 receptors. We report here that one of the constructs expresses a functional receptor that contains the serotonergic channel still blocked by Ca2+ ions, but is activated by nicotinic ligands and potentiated by external Ca2+ ions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 19:15:43