Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
FOOD EFFICIENCY IN RATS FOLLOWING BRAIN-LESIONS WHICH AFFECT TARGET BODY-SIZE - IMPLICATIONS ON THE SET-POINT FOR TARGET SIZE
Autore:
MOSIER HD; CRINELLA FM; YU J; CULLER FC; JANSONS RA;
Indirizzi:
UNIV CALIF IRVINE,DEPT PEDIAT IRVINE CA 92717 UNIV CALIF IRVINE,DEPT PHYS MED & REHABIL IRVINE CA 92717 STATE DEV RES INST COSTA MESA CA 00000
Titolo Testata:
Growth, development and aging
fascicolo: 4, volume: 57, anno: 1993,
pagine: 223 - 231
SICI:
1041-1232(1993)57:4<223:FEIRFB>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
DORSOMEDIAL HYPOTHALAMIC NUCLEUS; CATCH-UP GROWTH; HEAD-IRRADIATED RAT; REGULATORY DEFICITS; HORMONE SECRETION; RETARDED RATS; X-IRRADIATION; DMNL RATS; WEIGHT; FAILURE;
Keywords:
BRAIN; DORSOMEDIAL HYPOTHALAMIC NUCLEUS; ENERGY METABOLISM; FOOD EFFICIENCY; GROWTH; RAT; SET POINT; SUBSTANTIA-NIGRA; TARGET SIZE; X-IRRADIATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
H.D. Mosier et al., "FOOD EFFICIENCY IN RATS FOLLOWING BRAIN-LESIONS WHICH AFFECT TARGET BODY-SIZE - IMPLICATIONS ON THE SET-POINT FOR TARGET SIZE", Growth, development and aging, 57(4), 1993, pp. 223-231

Abstract

Target size, i.e. body size appropriate for age, may be reset by bilateral lesions of several brain areas. The mechanism for control of target body size is unknown, but some of the loci have marked effects on gustatory behavior and/or energy metabolism. We have tested the possibility that a disturbance in energy metabolism may be a common factor in resetting target size. Food efficiency for body weight gain and for metabolic size (the 0.75 power of body weight) was determined in rats that were experimentally stunted by neonatal head-irradiation or by bilateral electrolytic lesions produced soon after weaning in the dorsomedial hypothalamic nuclei (DMH) or the substantia nigra (SN). The irradiations were carried out in males and females; the surgical lesions were produced only in males. Observations were carried out from weaningthrough early adulthood. Subgroups of irradiated rats and controls were fasted for 48 hours at 40 days of age. Irradiated rats had reduced food efficiency for weight gain and for metabolic size, more marked inmales than in females. DMH or SN lesions did not change food efficiency for weight gain. Food efficiency for metabolic size increased afterDMH lesions and declined after SN lesions. During refeeding after a fast, irradiated rats showed a normal transient increase in food efficiency for weight gain, but not for-metabolic size. The differences in food efficiency following different lesions tend to exclude altered energy metabolism as a common factor in the reset of target body size. Although, the mechanism for resetting target size in these models remains unknown. the fact that lesions of several brain areas produce a reset strongly suggests that target size depends on a neural network.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 00:40:44