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Titolo:
IMMUNOSUPPRESSIVE EFFECTS OF 17-BETA-ESTRADIOL ON COLLAGEN-INDUCED ARTHRITIS IN MICE
Autore:
MATSUSHITA I; MATSUNO H; KADOWAKI KM; NAKAZAWA F; OKADA C; TSUJI H;
Indirizzi:
TOYAMA MED & PHARMACEUT UNIV,DEPT ORTHOPAED,2630 SUGITANI TOYAMA TOYAMA 93001 JAPAN
Titolo Testata:
International journal of immunotherapy
fascicolo: 3, volume: 9, anno: 1993,
pagine: 189 - 197
SICI:
0255-9625(1993)9:3<189:IEO1OC>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
ESTROGEN-INDUCED SUPPRESSION; RHEUMATOID-ARTHRITIS; II COLLAGEN; DBA/1 MICE; ORAL-CONTRACEPTIVES; STEROID-HORMONES; IMMUNE-SYSTEM; LYMPHOCYTES; PREGNANCY; WOMEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
I. Matsushita et al., "IMMUNOSUPPRESSIVE EFFECTS OF 17-BETA-ESTRADIOL ON COLLAGEN-INDUCED ARTHRITIS IN MICE", International journal of immunotherapy, 9(3), 1993, pp. 189-197

Abstract

The effects of oestradiol on collagen-induced arthritis (CIA) in ovariectomized mice was studied. Oestradiol suppressed the incidence and severity of arthritis, with a significant decrease in the CD4/CD8 ratioin lymphoid organs, followed by suppression of serum anti-type II collagen antibodies. The CD4/CD8 ratio was first decreased in the thymus,and then in the spleen and regional lymph nodes, followed by a changein the serum antibody titre and the clinical manifestations of CIA. These results suggest that oestradiol has an immunosuppressive effect on the progression of CIA through alteration of lymphocyte subsets.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 01:22:18