Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
DECLINE IN RESPONSE TO NICOTINE IN AGED RAT STRIATUM - CORRELATION WITH A DECREASE IN A SUBPOPULATION OF NICOTINIC RECEPTORS
Autore:
SCHULZ DW; KUCHEL GA; ZIGMOND RE;
Indirizzi:
CASE WESTERN RESERVE UNIV,SCH MED,DEPT NEUROSCI,10900 EUCLID AVE CLEVELAND OH 44106 HARVARD UNIV,SCH MED,DEPT BIOL CHEM & MOLEC PHARMACOL BOSTON MA 02115 HARVARD UNIV,SCH MED,DIV AGING BOSTON MA 02115 BETH ISRAEL HOSP,DEPT MED BOSTON MA 02215 BRIGHAM & WOMENS HOSP BOSTON MA 02115
Titolo Testata:
Journal of neurochemistry
fascicolo: 6, volume: 61, anno: 1993,
pagine: 2225 - 2232
SICI:
0022-3042(1993)61:6<2225:DIRTNI>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
BINDING-SITES; ACETYLCHOLINE-RECEPTORS; CHOLINERGIC RECEPTORS; ALZHEIMERS-DISEASE; NEURONAL BUNGAROTOXIN; ALPHA-BUNGAROTOXIN; DOPAMINE RELEASE; CEREBRAL-CORTEX; BRAIN; LOCALIZATION;
Keywords:
NICOTINIC RECEPTORS; STRIATUM; RATS; AGING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
D.W. Schulz et al., "DECLINE IN RESPONSE TO NICOTINE IN AGED RAT STRIATUM - CORRELATION WITH A DECREASE IN A SUBPOPULATION OF NICOTINIC RECEPTORS", Journal of neurochemistry, 61(6), 1993, pp. 2225-2232

Abstract

Specific and reproducible changes involving the cholinergic and dopaminergic systems have been described in both the aging rodent and the human nervous system. Nevertheless, relatively little information is available on changes in nicotinic cholinergic receptors occurring in normal aging, and there have been few attempts to correlate alterations in receptor densities with changes in nicotinic actions. We have utilized the nicotine-mediated stimulation of endogenous dopamine efflux in a striatal slice preparation as a functional index of responsiveness to nicotine in aging. Following incubation with nicotine, this efflux was significantly lower in 25-month-old (aged) as opposed to 4-month-old (young) rats. In contrast, the release of striatal dopamine following a high-potassium stimulus was similar at both ages. Binding studies in young and aged animals did not reveal any significant change with age in the total number of striatal nicotinic receptors recognized by either [H-3]nicotine or the neuronal nicotinic antagonist I-125-neuronal bungarotoxin. However, there was a nearly 800/. decline in the subpopulation of striatal nicotinic receptors jointly recognized by both nicotine and neuronal bungarotoxin, but not by alpha-bungarotoxin. Quantitative autoradiography demonstrated declines with age in this receptor subtype in several brain regions examined. Decrements in this specific subpopulation of nicotinic receptors or in the nerve cells expressing these receptors may contribute to the functional declines that takeplace in the aging motor and visual systems. Key Words: Nicotinic

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 12:55:06