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Titolo:
,2,3,4-TETRAHYDRO-2-METHYL-4,6,7-ISOQUINOLINETRIOL DEPLETES CATECHOLAMINES IN RAT-BRAIN
Autore:
LIPTROT J; HOLDUP D; PHILLIPSON O;
Indirizzi:
UNIV BRISTOL,SCH MED SCI,DEPT ANAT,UNIV WALK BRISTOL BS8 1TD AVON ENGLAND UNIV BRISTOL,SCH MED SCI,DEPT ANAT,UNIV WALK BRISTOL BS8 1TD AVON ENGLAND UNIV BRISTOL,SCH MED SCI,DEPT PHARMACOL BRISTOL BS8 1TD AVON ENGLAND
Titolo Testata:
Journal of neurochemistry
fascicolo: 6, volume: 61, anno: 1993,
pagine: 2199 - 2206
SICI:
0022-3042(1993)61:6<2199:,DC>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE (MPTP)-INDUCED NEUROTOXICITY; 1-METHYL-4-PHENYLPYRIDINIUM ION MPP+; MONOAMINE-OXIDASE; DOPAMINERGIC NEUROTOXICITY; TYROSINE-HYDROXYLASE; SUBSTANTIA-NIGRA; MITOCHONDRIAL RESPIRATION; CHRONIC PARKINSONISM; BIOLOGICAL-ACTIVITY; MPTP ANALOGS;
Keywords:
DOPAMINE; MPTP; PARKINSONS DISEASE; ,2,3,4-TETRAHYDRO-2-METHYL-4,6,7-ISOQUINOLINETRIOL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
57
Recensione:
Indirizzi per estratti:
Citazione:
J. Liptrot et al., ",2,3,4-TETRAHYDRO-2-METHYL-4,6,7-ISOQUINOLINETRIOL DEPLETES CATECHOLAMINES IN RAT-BRAIN", Journal of neurochemistry, 61(6), 1993, pp. 2199-2206

Abstract

,2,3,4-Tetrahydro-2-methyl-4,6,7-isoquinolinetriol (TMIQ) was synthesised and tested for activity as a dopamine-depleting agent in rat brain. After intracerebroventricular infusion, TMIQ caused reductions in dopamine concentrations in substantia nigra, striatum, hypothalamus, and dorsal raphe, and reduction in noradrenaline concentrations in locuscoeruleus. TMIQ also reduced 5-hydroxytryptamine concentrations in dorsal raphe and substantia nigra, although with a lower potency. Comparisons between TMIQ and MPTP showed that they were approximately equipotent in depleting dopamine in the substantia nigra, hypothalamus, and dorsal raphe. Pre-treatment of animals with a combination of monoamineoxidase A and B inhibitors completely prevented the TMIQ-induced reductions in dopamine concentrations in substantia nigra and hypothalamus. Direct unilateral intrastriatal injections of TMIQ produced marked ipsilateral reductions in striatal dopamine, correlating with a behavioural response consisting of turning towards the side of injection. Theresults suggest that TMIQ should be evaluated further as a possible MPTP-like compound, which may derive from endogenous beta-hydroxylated catecholamines.

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Documento generato il 09/07/20 alle ore 01:22:12