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Titolo:
INTRACORONARY PAPAVERINE BUT NOT ADENOSINE REDUCES REGIONAL VENTRICULAR-FUNCTION
Autore:
MARTIN SE; SCHMARKEY LS; OH DJ; PATTERSON RE;
Indirizzi:
EMORY CRAWFORD LONG HOSP,CARLYLE FRASER HEART CTR,DEPT MED CARDIOL,550 PEACHTREE ST NE ATLANTA GA 30365 EMORY CRAWFORD LONG HOSP,CARLYLE FRASER HEART CTR,DEPT MED CARDIOL,550 PEACHTREE ST NE ATLANTA GA 30365 EMORY UNIV,SCH MED,DEPT PHYSIOL ATLANTA GA 30322
Titolo Testata:
Cardiovascular Research
fascicolo: 11, volume: 27, anno: 1993,
pagine: 2028 - 2036
SICI:
0008-6363(1993)27:11<2028:IPBNAR>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
IDEAL CORONARY VASODILATOR; ARTERY DISEASE; FLOW; CIRCULATION; RELAXATION; ISCHEMIA; RESERVE;
Keywords:
PAPAVERINE; ADENOSINE; VENTRICULAR WALL MOTION; VASODILATOR AGENTS; MYOCARDIAL FUNCTION; CORONARY BLOOD FLOW; CORONARY VASCULAR RESERVE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
S.E. Martin et al., "INTRACORONARY PAPAVERINE BUT NOT ADENOSINE REDUCES REGIONAL VENTRICULAR-FUNCTION", Cardiovascular Research, 27(11), 1993, pp. 2028-2036

Abstract

Objectives: Whether intracoronary papaverine or adenosine leads to reductions in regional left ventricular function was tested. Methods: Fifteen anaesthetised dogs were prepared to record aortic pressure, leftventricular pressure dP/dt, electrocardiogram, regional ventricular shortening, and phasic and mean left circumflex coronary blood flow, and to.give intracoronary boluses of papaverine (2, 4, or 6 mg) or adenosine (0.37 and 1.87 mg). Results: Injected doses were chosen to mimic those given in the clinical setting. Papaverine (6 mg) reduced aortic pressure (mean 96(SD 17) to 89(18) mm Hg; p < 0.05), segmental shortening of the infused left circumflex zone (12(5) to 7(9)%; p<0.05), and area of the pressure-length loop of the infused zone (120(71) to 53(47) mm.mm Hg; p < 0.05). Papaverine increased coronary blood flow (48(25) to 259(95) ml.min-1; p < 0.05), coronary vascular conductance (0.40(0.20) to 2.93(0.94) ml.mm Hg-1.min-1; p<0.05), heart rate (88(27) to 100(28) beats.min-1; p < 0.05), and the segmental shortening (17(6) to 19(3)% p < 0.05) and area of the pressure-length loop (1 30(32) to 177(33) mm-mm Hg; p < 0.05) of the non-infused left anterior descending region. The hyperaemia elicited by papaverine was greater than that of reactive hyperaemia (p = 0.008). Papaverine also increased the QT interval corrected for heart rate (0.35(0.04) to 0.45(0.05) s; p < 0.05). When adenosine was given, coronary blood flow and coronary vascular conductance were increased to similar degrees as those during reactive hyperaemia (41(12) to 210(75) ml.min-1 and 0.46(0.14) to 2.43(0.83) mm Hg-ml-1.min-1, respectively; NS). No effects on segmental shortening or the area of the pressure-length loop in either zone were found. Also, adenosine had no effect on the QT interval. Conclusions: These adverse effects of intracoronary papaverine have important implications in its use in patients, particularly in those in whom abnormal cardiac function already exists. Adenosine, on the other hand, seems to be without deleterious effects.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 22:12:19