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Titolo:
EPOC-1 - A POU-DOMAIN GENE EXPRESSED IN MURINE EPIDERMAL BASAL CELLS AND THYMIC STROMAL CELLS
Autore:
YUKAWA K; YASUI T; YAMAMOTO A; SHIKU H; KISHIMOTO T; KIKUTANI H;
Indirizzi:
OSAKA UNIV,INST MOLEC & CELLULAR BIOL,1-3 YAMADAOKA SUITA OSAKA 565 JAPAN OSAKA UNIV,INST MOLEC & CELLULAR BIOL,1-3 YAMADAOKA SUITA OSAKA 565 JAPAN OSAKA UNIV,SCH MED,DEPT MED 3 OSAKA JAPAN NAGASAKI UNIV,SCH DENT,DEPT FIXED PROSTHODONT NAGASAKI 852 JAPAN NAGASAKI UNIV,SCH MED NAGASAKI 852 JAPAN
Titolo Testata:
Gene
fascicolo: 2, volume: 133, anno: 1993,
pagine: 163 - 169
SICI:
0378-1119(1993)133:2<163:E-APGE>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSCRIPTION FACTOR; TRANSGENIC MICE; GROWTH-HORMONE; C-ELEGANS; PROTEIN; PIT-1; CONTAINS; DIFFERENTIATION; IDENTIFICATION; HOMEODOMAIN;
Keywords:
HOMEOBOX; DEVELOPMENT; TRANSCRIPTION FACTOR; OCTAMER-BINDING EPOC-1 PROTEIN; STRATIFIED SQUAMOUS EPITHELIA; KERATIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
K. Yukawa et al., "EPOC-1 - A POU-DOMAIN GENE EXPRESSED IN MURINE EPIDERMAL BASAL CELLS AND THYMIC STROMAL CELLS", Gene, 133(2), 1993, pp. 163-169

Abstract

POU-domain transcription factors are known as developmental regulators which control organ development and cell phenotypes. In order to clarify the roles of POU-domain transcription factors in cell differentiation, we cloned a novel POU family gene, Epoc-1, from a murine thymus cDNA library. The amino acid (aa) sequence of the POU-specific domain of Epoc-1 is almost identical to those of Oct-1 and Oct-2. However, within the POU-homeodomain, 13 out of 60 aa differ between Epoc-1 and Oct-2. Recombinant Epoc-1 products were found to bind specifically to the octamer sequence. Epoc-1 was found to be expressed in skin, thymus, stomach and testis. In situ hybridization experiments and RNase protection assays indicated that Epoc-1 is expressed in the epidermal basal cells of the skin, which contain stem cells unipotent for keratinocytedifferentiation and in thymic stromal elements. These results suggestthat Epoc-1 might be one of the developmental regulators which controls epidermal development and thymic organogenesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 08:14:09