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Titolo:
THE NON-PSYCHOTROPIC CANNABINOID (-(3S,4S)-7-HYDROXY-DELTA-6-TETRAHYDROCANNABINOL 1,1-DIMETHYLHEPTYL (HU-211) ATTENUATES N-METHYL-D-ASPARTATE RECEPTOR-MEDIATED NEUROTOXICITY IN PRIMARY CULTURES OF RAT FOREBRAIN())
Autore:
NADLER V; MECHOULAM R; SOKOLOVSKY M;
Indirizzi:
TEL AVIV UNIV,GEORGE S WISE FAC LIFE SCI,DEPT BIOCHEM IL-69978 TEL AVIV ISRAEL TEL AVIV UNIV,GEORGE S WISE FAC LIFE SCI,DEPT BIOCHEM IL-69978 TEL AVIV ISRAEL HEBREW UNIV JERUSALEM,FAC MED,BRETTLER MED RES CTR IL-91120 JERUSALEMISRAEL
Titolo Testata:
Neuroscience letters
fascicolo: 1-2, volume: 162, anno: 1993,
pagine: 43 - 45
SICI:
0304-3940(1993)162:1-2<43:TNC(>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
BINDING-SITES; GLUTAMATE; BRAIN; DAMAGE; NEURONS;
Keywords:
GLUTAMATE TOXICITY; N-METHYL-D-ASPARTATE TOXICITY; CANNABINOID; HU-211;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
V. Nadler et al., "THE NON-PSYCHOTROPIC CANNABINOID (-(3S,4S)-7-HYDROXY-DELTA-6-TETRAHYDROCANNABINOL 1,1-DIMETHYLHEPTYL (HU-211) ATTENUATES N-METHYL-D-ASPARTATE RECEPTOR-MEDIATED NEUROTOXICITY IN PRIMARY CULTURES OF RAT FOREBRAIN())", Neuroscience letters, 162(1-2), 1993, pp. 43-45

Abstract

The non-psychotropic cannabinoid (+)-(3S,4S)-7-hydroxy-DELTA6-tetrahydrocannabinol 1,1-dimethylheptyl (HU-211), a stereoselective inhibitorof the N-methyl-D-aspartate (NMDA) receptor, protects primary cultures of rat forebrain against NMDA receptor-mediated neurotoxicity. Cell mortality produced by exposure for 10 min to NMDA or glutamate was reduced to approximately 18 or 27%, respectively, by application of 50 muM HU-211 for 10-15 min during or after exposure of cultures to excitatory amino acid. This effect of HU-211 was dependent on its concentration (EC50 = 8.7 +/- 4 muM). HU-211 also reduced the toxicity induced bybrief exposure (10 min) to kainate or quisqualate, though less effectively. HU-211 may therefore prove useful as a non-psychoactive drug that protects against neurotoxicity mediated by the NMDA receptor.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 16:32:57