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Titolo:
ATYPICAL NEUROLEPTICS, PHARMACOLOGY AND C LINICAL RELEVANCE
Autore:
KLAGES U; HIPPIUS H; MULLERSPAHN F;
Indirizzi:
UNIV MUNICH,PSYCHIAT KLIN,NUSSBAUMSTR 7 D-80336 MUNICH GERMANY
Titolo Testata:
Fortschritte der Neurologie, Psychiatrie
fascicolo: 11, volume: 61, anno: 1993,
pagine: 390 - 398
SICI:
0720-4299(1993)61:11<390:ANPACL>2.0.ZU;2-8
Fonte:
ISI
Lingua:
GER
Soggetto:
ANTIPSYCHOTIC-DRUGS; HALOPERIDOL; CLOZAPINE; INVIVO; SCHIZOPHRENIA; METABOLISM; RECEPTORS; SYMPTOMS; ZOTEPINE; BINDING;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
U. Klages et al., "ATYPICAL NEUROLEPTICS, PHARMACOLOGY AND C LINICAL RELEVANCE", Fortschritte der Neurologie, Psychiatrie, 61(11), 1993, pp. 390-398

Abstract

Since the development of clozapine the investigation of atypical neuroleptic compounds has become increasingly relevant. Compared with classic neuroleptics they are distinguished by either fewer or absent (clozapine) extrapyramidal side effects, some of them also by lower increases of serum prolactin concentrations. Pharmacologically they are a group of heterogeneous substances. At the level of transmitter systems ahigh 5HT2/D2-ratio is regarded as the best criterion to distinguish between atypical and classic neuroleptics. Further differences involve:the preferred effects of atypical neuroleptics on mesolimbic D2 receptors compared to striatal dopaminergic neurotransmission; a higher potency of some atypical neuroleptics to antagonize D1-receptors; the increase of serum corticosterone concentrations by some of the atypical neuroleptics. The possible effects of atypical neuroleptics and their clinical relevance are discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 16:57:31