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Titolo:
PROLONGED HEMOLYTIC-ANEMIA IN MALARIA AND AUTOANTIBODIES AGAINST TRIOSEPHOSPHATE ISOMERASE
Autore:
RITTER K; KUHLENCORD A; THOMSSEN R; BOMMER W;
Indirizzi:
UNIV GOTTINGEN,ZENTRUM HYG & HUMANGENET,MED MIKROBIOL ABT D-37075 GOTTINGEN GERMANY UNIV GOTTINGEN,DEPT TROP MED D-37075 GOTTINGEN GERMANY
Titolo Testata:
Lancet
fascicolo: 8883, volume: 342, anno: 1993,
pagine: 1333 - 1334
SICI:
0140-6736(1993)342:8883<1333:PHIMAA>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMODIUM-FALCIPARUM MALARIA; IGM ANTIBODIES; ANEMIA;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
10
Recensione:
Indirizzi per estratti:
Citazione:
K. Ritter et al., "PROLONGED HEMOLYTIC-ANEMIA IN MALARIA AND AUTOANTIBODIES AGAINST TRIOSEPHOSPHATE ISOMERASE", Lancet, 342(8883), 1993, pp. 1333-1334

Abstract

Prolonged haemolysis may accompany infection with Plasmodium falciparum. We observed prolonged haemolysis in 4 of 10 patients with this type of malaria after parasitological cure. IgM antibodies specific for the glycolytic enzyme triosephosphate isomerase were detected in these patients' sera. Clinical recovery and a decrease in haemolysis coincided with a fall in these autoantibodies. In vitro, affinity purified autoantibodies isolated from the sera directed against triosephosphate isomerase induced lysis of erythrocytes and activation of complement asshown by the Cr-51 release assay. We assume that autoantibodies against triosephosphate isomerase contribute to the development of prolonged haemolysis and anaemia in P. falciparum malaria.

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Documento generato il 05/12/20 alle ore 13:47:01