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Titolo:
PHARMACOLOGY OF MOCLOBEMIDE
Autore:
HAEFELY W; BURKARD WP; CESURA A; COLZI A; KETTLER R; LOREZ HP; MARTIN JR; MOREAU JL; RICHARDS JG; SCHAFFNER R; SCHERSCHLICHT R; SEPINWALL J; DAPRADA M;
Indirizzi:
F HOFFMANN LA ROCHE & CO LTD,DEPT CNS RES,PRECLIN RES,DIV PHARMA,BLDG69-412 CH-4002 BASEL SWITZERLAND F HOFFMANN LA ROCHE & CO LTD,DEPT CNS RES,PRECLIN RES,DIV PHARMA,BLDG69-412 CH-4002 BASEL SWITZERLAND
Titolo Testata:
Clinical neuropharmacology
, volume: 16, anno: 1993, supplemento:, 2
pagine: 190000008 - 190000018
SICI:
0362-5664(1993)16:<190000008:POM>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
OXIDASE TYPE-A; MONOAMINE-OXIDASE; REVERSIBLE INHIBITOR; HUMAN BRAIN; RATS; ANTIDEPRESSANT; MICRODIALYSIS; DOPAMINE; PROFILE; INVIVO;
Keywords:
MAO-A; ANIMAL MODELS; ANTIDEPRESSANT ACTIVITY; NEUROPROTECTIVE ACTION; MOCLOBEMIDE; ANTIHYPERLIPIDEMICS; MAO INHIBITION; TYRAMINE POTENTIATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
W. Haefely et al., "PHARMACOLOGY OF MOCLOBEMIDE", Clinical neuropharmacology, 16, 1993, pp. 190000008-190000018

Abstract

Moclobemide is a reversible inhibitor of monoamine oxidase (MAO) withclear preference for the A type (so-called RIMA). The enzyme inhibition shows complex kinetics, and the molecular mechanism of interaction with the enzyme is not yet clear. Moclobemide increases the extracellular concentration of the monoamines in rat brain and decreases the level of their metabolites. Neither a loss nor a cumulation of activity has been observed after chronic treatment. Reversibility of MAO-A inhibition was demonstrated in vitro as well as in vivo. In various animal behavioral models, in particular in a novel model of stress-induced anhedonia, moclobemide was as effective as standard antidepressants. Moclobemide improves cognitive functions that are impaired in experimental situations. A neuroprotective action is seen in rats subjected to transient global ischemia/-hypoxia. Moclobemide lacks anticholinergic and other effects and only slightly increases the pressor effect of orally administered tyramine. Possible links between MAO-A inhibition and the various effects of moclobemide on brain function are discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 04:43:43