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Titolo:
CLONING AND PHARMACOLOGICAL CHARACTERIZATION OF A RAT MU-OPIOID RECEPTOR
Autore:
THOMPSON RC; MANSOUR A; AKIL H; WATSON SJ;
Indirizzi:
UNIV MICHIGAN,MENTAL HLTH RES INST ANN ARBOR MI 48109
Titolo Testata:
Neuron
fascicolo: 5, volume: 11, anno: 1993,
pagine: 903 - 913
SICI:
0896-6273(1993)11:5<903:CAPCOA>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
INHIBIT ADENYLATE-CYCLASE; SITE-DIRECTED ALKYLATION; KAPPA-OPIATE AGONISTS; NALORPHINE-LIKE DRUGS; CHRONIC SPINAL DOG; BINDING-SITES; HIGH-AFFINITY; HETEROLOGOUS DESENSITIZATION; EXPRESSION CLONING; MORPHINE-LIKE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
60
Recensione:
Indirizzi per estratti:
Citazione:
R.C. Thompson et al., "CLONING AND PHARMACOLOGICAL CHARACTERIZATION OF A RAT MU-OPIOID RECEPTOR", Neuron, 11(5), 1993, pp. 903-913

Abstract

We have isolated a rat cDNA clone that displays 75% amino acid homology with the mouse delta and rat kappa opioid receptors. The cDNA (designated pRMuR-12) encodes a protein of 398 amino acids comprising, in part, seven hydrophobic domains similar to those described for other G protein-linked receptors. Data from binding assays conducted with COS-1 cells transiently transfected with a CMV mammalian expression vectorcontaining the full coding region of pRMuR-12 demonstrated mu receptor selectivity. In situ hybridization mRNA analysis revealed an mRNA distribution in rat brain that corresponds well to the distribution of binding sites labeled with mu-selective ligands. Based upon these observations, we conclude that pRMuR-12 encodes a mu opioid receptor.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 22:21:28