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Titolo:
THE WNT-1 PROTOONCOGENE INDUCES CHANGES IN MORPHOLOGY, GENE-EXPRESSION, AND GROWTH-FACTOR RESPONSIVENESS IN PC12 CELLS
Autore:
SHACKLEFORD GM; WILLERT K; WANG JW; VARMUS HE;
Indirizzi:
CHILDRENS HOSP LOS ANGELES,DIV HEMATOL ONCOL LOS ANGELES CA 90027 UNIV SO CALIF,SCH MED,DEPT PEDIAT LOS ANGELES CA 90033 UNIV SO CALIF,SCH MED,DEPT MICROBIOL LOS ANGELES CA 90033 UNIV CALIF SAN FRANCISCO,DEPT BIOCHEM & BIOPHYS SAN FRANCISCO CA 94143 UNIV CALIF SAN FRANCISCO,DEPT MICROBIOL & IMMUNOL SAN FRANCISCO CA 94143
Titolo Testata:
Neuron
fascicolo: 5, volume: 11, anno: 1993,
pagine: 865 - 875
SICI:
0896-6273(1993)11:5<865:TWPICI>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
FACTOR-INDUCED DIFFERENTIATION; EMBRYONAL CARCINOMA-CELLS; MAMMARY-TUMOR VIRUS; PHEOCHROMOCYTOMA CELLS; XENOPUS EMBRYOS; TRANSGENIC MICE; NEURONAL DIFFERENTIATION; DEVELOPMENTAL EXPRESSION; TRANSIENT EXPRESSION; INT-1 PROTOONCOGENE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
70
Recensione:
Indirizzi per estratti:
Citazione:
G.M. Shackleford et al., "THE WNT-1 PROTOONCOGENE INDUCES CHANGES IN MORPHOLOGY, GENE-EXPRESSION, AND GROWTH-FACTOR RESPONSIVENESS IN PC12 CELLS", Neuron, 11(5), 1993, pp. 865-875

Abstract

The product of the Wnt-1 proto-oncogene is a secreted glycoprotein that is normally produced in regions of the embryonic neural tube. We show here that expression of mouse Wnt-1 cDNA in the rat PC12 pheochromocytoma cell line causes a dramatic conversion from a round to a flat cell morphology. In addition, PC12 cells expressing Wnt-1 (PC12/Wnt-1) fail to extend neurites after treatment with NGF, despite the presenceand activation of high affinity NGF receptors encoded by the trk geneand the induction of early response genes. Furthermore, PC12/Wnt-1 cells fail to express several neuron- and chromaffin-specific genes, indicating that PC12/Wnt-1 cells have assumed a new phenotype. Although NGF and FGF utilize similar signal transduction pathways in PC12 cells,only FGF is capable of inducing a morphological response and synthesis of transin mRNA in PC12/Wnt-1 cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 08:58:07