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Titolo:
NONCOORDINATED EXPRESSION OF ALPHA-SUBUNIT, BETA-SUBUNIT, AND GAMMA-SUBUNIT MESSENGER-RNAS OF EPITHELIAL NA-TRACT( CHANNEL ALONG RAT RESPIRATORY)
Autore:
FARMAN N; TALBOT CR; BOUCHER R; FAY M; CANESSA C; ROSSIER B; BONVALET JP;
Indirizzi:
UNIV PARIS 07,INSERM U246,BP416 F-75870 PARIS 18 FRANCE UNIV PARIS 07,INSERM U246 F-75018 PARIS 18 FRANCE UNIV N CAROLINA,DIV PULM DIS CHAPEL HILL NC 27599 UNIV LAUSANNE,INST PHARMACOL & TOXICOL CH-1005 LAUSANNE SWITZERLAND
Titolo Testata:
American journal of physiology. Cell physiology
fascicolo: 1, volume: 41, anno: 1997,
pagine: 131 - 141
SICI:
0363-6143(1997)41:1<131:NEOABA>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-SPECIFIC EXPRESSION; AIRWAY ION-TRANSPORT; CYSTIC-FIBROSIS; BIOELECTRIC PROPERTIES; SUBMUCOSAL GLANDS; LUNG; CONDUCTANCE; ELECTROLYTE; REGULATOR; CULTURE;
Keywords:
AMILORIDE-SENSITIVE SODIUM CHANNEL; RAT EPITHELIAL SODIUM CHANNEL; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; SUBMUCOSAL GLANDS; RESPIRATORY EPITHELIUM; ESOPHAGUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
N. Farman et al., "NONCOORDINATED EXPRESSION OF ALPHA-SUBUNIT, BETA-SUBUNIT, AND GAMMA-SUBUNIT MESSENGER-RNAS OF EPITHELIAL NA-TRACT( CHANNEL ALONG RAT RESPIRATORY)", American journal of physiology. Cell physiology, 41(1), 1997, pp. 131-141

Abstract

Na+ reabsorption from the epithelial surface of the respiratory tractplays a fundamental. role in respiratory physiology. As in the epithelia of the renal collecting tubule and distal colon, Na+ enters acrossthe luminal surface of respiratory epithelial cells via a recently cloned amiloride-sensitive multisubunit (alpha, beta, gamma) epithelial Na+ channel. We have examined the cellular expression at the mRNA level of the alpha-, beta-, and gamma-subunits of rat epithelial Na+ channel (rENaC) in the rat lung and upper airway epithelial cells using in situ hybridization. A large prevalence of alpha- and gamma-rENaC subunit expression (over beta) was found in tracheal epithelium, in a subpopulation of alveolar cells, presumably type II pneumocytes, and in nasal and tracheal gland acini. In contrast, equivalent levels of expression of all three subunits were detected in bronchiolar epithelium and in rat nasal gland ducts. This diversity of expression may reflect cell-specific functions of the amiloride-sensitive Na+ channel along the respiratory tract.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 21:36:02