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Titolo:
PHENOTYPICALLY DISTINCT SUBSETS OF CD4(-CELLS INDUCE OR PROTECT FROM CHRONIC INTESTINAL INFLAMMATION IN C - B-17 SCID MICE() T)
Autore:
POWRIE F; LEACH MW; MAUZE S; CADDLE LB; COFFMAN RL;
Indirizzi:
DNAX RES INST MOLEC & CELLULAR BIOL INC,901 CALIF AVE PALO ALTO CA 94040 SCHERING PLOUGH CORP,RES INST LAFAYETTE NJ 07848
Titolo Testata:
International immunology
fascicolo: 11, volume: 5, anno: 1993,
pagine: 1461 - 1471
SICI:
0953-8178(1993)5:11<1461:PDSOCI>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
LEUKOCYTE-COMMON ANTIGEN; CYCLOSPORINE-INDUCED AUTOIMMUNITY; INHIBITS CYTOKINE PRODUCTION; POLYMERASE CHAIN-REACTION; MONOCLONAL-ANTIBODY; LYMPHOCYTES-T; FUNCTIONAL-HETEROGENEITY; DIFFERENTIAL EXPRESSION; INTERFERON-GAMMA; GENE-EXPRESSION;
Keywords:
CD45; CD4(+) T-CELL SUBSETS; COLITIS; IMMUNOREGULATION; INFLAMMATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
61
Recensione:
Indirizzi per estratti:
Citazione:
F. Powrie et al., "PHENOTYPICALLY DISTINCT SUBSETS OF CD4(-CELLS INDUCE OR PROTECT FROM CHRONIC INTESTINAL INFLAMMATION IN C - B-17 SCID MICE() T)", International immunology, 5(11), 1993, pp. 1461-1471

Abstract

CD4+ T cells in the mouse can be subdivided into two fractions based on the level of expression of the CD45RB determinant. Previous studieshave shown that these subsets are functionally distinct. We have further characterized the properties of these subpopulations in vivo by injecting them into C. B-17 scid mice. The animals restored with the CD45RB(high)CD4+ T cell population developed a lethal wasting disease with severe mononuclear cell infiltrates into the colon and elevated levels of IFN-gamma mRNA. In contrast, animals restored with the reciprocal CD45RB(low) subset or with unfractionated CD4+ T cells did not develop the wasting or colitis. Importantly, the co-transfer of the CD45RB(low) population with the CD45RB(high) population prevented the wastingdisease and colitis. These data indicate that important regulatory interactions occur between the CD45RB(high) and CD45RB(low)CD4+ T cell subsets and that disruption of this mechanism has fatal consequences.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 02:55:55