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Titolo:
DISTINCT INTRACYTOPLASMIC SEQUENCES ARE REQUIRED FOR ENDOCYTOSIS AND PHAGOCYTOSIS VIA MURINE FC-GAMMA-RII IN MAST-CELLS
Autore:
DAERON M; MALBEC O; LATOUR S; BONNEROT C; SEGAL DM; FRIDMAN WH;
Indirizzi:
INST CURIE,INSERM,U255,IMMUNOL CELLULAIRE & CLIN LAB,26 RUE ULM F-75005 PARIS FRANCE NCI,EXPTL IMMUNOL BRANCH,IMMUNE TARGETING SECT BETHESDA MD 20892
Titolo Testata:
International immunology
fascicolo: 11, volume: 5, anno: 1993,
pagine: 1393 - 1401
SICI:
0953-8178(1993)5:11<1393:DISARF>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
BASOPHILIC LEUKEMIA-CELLS; COATED PIT LOCALIZATION; IMMUNOGLOBULIN-E; BOUND LIGANDS; IGE RECEPTORS; MACROPHAGE; INTERNALIZATION; ANTIBODY; SUBUNIT; DOMAINS;
Keywords:
IMMUNE COMPLEXES; MURINE LOW-AFFINITY RECEPTORS FOR IGG; RAT BASOPHILIC LEUKEMIA CELLS; RECEPTOR-MEDIATED INTERNALIZATION; SITE-DIRECTED MUTAGENESIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
M. Daeron et al., "DISTINCT INTRACYTOPLASMIC SEQUENCES ARE REQUIRED FOR ENDOCYTOSIS AND PHAGOCYTOSIS VIA MURINE FC-GAMMA-RII IN MAST-CELLS", International immunology, 5(11), 1993, pp. 1393-1401

Abstract

In the present work, we studied the phagocytic and endocytic properties of murine FcgammaRII in mast cells. Mouse mast cells express high-affinity receptors for monomeric IgE and three low-affinity receptors for complexed IgG: FcgammaRIIb1, FcgammaRIIb2, and FcgammaRIII. In previous studies we showed that, when aggregated by multivalent ligands, murine FcgammaRIIl, but not FcgammaRII, triggers the release of inflammatory mediators and cytokines by mast cells. Upon FcgammaR aggregation, mast cells not only release intracellular materials, they also internalize particulate and soluble immune complexes. We compared the ability of the two FcgammaRII isoforms to trigger phagocytosis and endocytosis in RBL-2H3 cells stably transfected with cDNAs encoding wild-type,deleted, and tyrosine mutant FcgammaRIIb1 or FcgammaRIIb2. We found that FcgammaRIIb2, but not FcgamaRIIb1, triggered both phagocytosis andendocytosis. We identified distinct intracytoplasmic sequences necessary for FcgammaRIIb2-mediated endocytosis and phagocytosis respectively, and we observed that two tyrosine residues, located in each of these sequences, are critical for endocytosis and/or phagocytosis. Our data indicate that the two internalization pathways diverge as early as signal transduction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 19:20:37