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Titolo:
6-[F-18]FLUORO-L-DOPA AND CEREBRAL BLOOD-FLOW IN UNILATERALLY MPTP-TREATED MONKEYS
Autore:
DOUDET DJ; WYATT RJ; CANNONSPOOR E; SUDDATH R; MCLELLAN CA; COHEN RM;
Indirizzi:
NIMH,LCM,IRP,CLIN BRAIN IMAGING SECT,BLDG 10-4N317,9000 ROCKVILLE PIKE BETHESDA MD 20892 NIMH,IRP,NEUROPSYCHIAT BRANCH BETHESDA MD 20892
Titolo Testata:
Journal of neural transplantation & plasticity
fascicolo: 1, volume: 4, anno: 1993,
pagine: 27 - 38
SICI:
0792-8483(1993)4:1<27:6ACBIU>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; BRAIN TRANSFER CONSTANTS; TIME UPTAKE DATA; DOPAMINERGIC-NEURONS; CHRONIC PARKINSONISM; GRAPHICAL EVALUATION; PET SCANS; METABOLISM; 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; HEMIPARKINSONISM;
Keywords:
BLOOD FLOW; F-18-DOPA; POSITRON EMISSION TOMOGRAPHY; MPTP; PARKINSONS DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
D.J. Doudet et al., "6-[F-18]FLUORO-L-DOPA AND CEREBRAL BLOOD-FLOW IN UNILATERALLY MPTP-TREATED MONKEYS", Journal of neural transplantation & plasticity, 4(1), 1993, pp. 27-38

Abstract

Intravenous administration of O-15-labeled water and 6-[F-18]-L-fluorodopa were used to assess abnormal striatal activity in monkeys after long-term recovery of unilateral lesions of the dopaminergic nigro-striatal system induced by the neurotoxin MPTP. PET data were examined inrelation to behavioral and biological parameters. Cerebral blood flowand 6-[F-18]-L-DOPA uptake were found to be significantly reduced in the lesioned striatum, compared to the unaffected side and to normal controls. There was no correlation between cerebral blood flow and any of the behavioral parameters. The uptake rate constant of F-18-DOPA from blood to striatum and the ratios of striatum to occipital areas were highly correlated to the concentrations of homovanillic acid in the cerebrospinal fluid of the same animals but not to the rotational behavior. This MPTP-induced model of striatal dopamine deficiency in primates presents similarities with idiopathic Parkinson's disease and may be used to evaluate the effects of dopaminergic lesions and transplants on brain function.

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Documento generato il 21/09/20 alle ore 03:08:03