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Titolo:
EPSTEIN-BARR-VIRUS SUBTYPE DISTRIBUTION IN ANGIOIMMUNOBLASTIC LYMPHADENOPATHY
Autore:
BORISCH B; CAIONI M; HURWITZ N; DOMMANNSCHERRER C; ODERMATT B; WAELTI E; LAENG RH; KRAFT R; LAISSUE J;
Indirizzi:
UNIV BERN,INST PATHOL,MURTENSTR 31 CH-3010 BERN SWITZERLAND UNIV BASEL,INST PATHOL CH-4051 BASEL SWITZERLAND UNIV ZURICH,DEPT PATHOL CH-8006 ZURICH SWITZERLAND
Titolo Testata:
International journal of cancer
fascicolo: 5, volume: 55, anno: 1993,
pagine: 748 - 752
SICI:
0020-7136(1993)55:5<748:ESDIAL>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-CELL LYMPHOMA; IMMUNOBLASTIC LYMPHADENOPATHY; B-CELLS; DNA; DYSPROTEINEMIA; LOCALIZATION; EXPRESSION; PREVALENCE; INFECTION; GENOMES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
B. Borisch et al., "EPSTEIN-BARR-VIRUS SUBTYPE DISTRIBUTION IN ANGIOIMMUNOBLASTIC LYMPHADENOPATHY", International journal of cancer, 55(5), 1993, pp. 748-752

Abstract

The tissues of 16 patients bearing a T-cell lymphoma of angioimmunoblastic lymphadenopathy type (AILD-TCL) were investigated for the distribution of Epstein-Barr virus (EBV) subtypes 1 and 2. EBV-association had been proven in these cases by polymerase chain reaction (PCR) for EBV-DNA, in situ hybridization (ISH) for EBV-encoded small nuclear RNAs(EBER) and immunohistology for EBV-encoded latent membrane protein (LMP). PCR and EBER-ISH produced mostly identical results, but some cases were positive with only one of the 2 methods employed. LMP was detected in a few large cells of 8/13 cases. Twelve cases were investigatedfor the distribution of EBV subtypes. One case contained EBV genome of subtype 2, 3 cases contained subtype 1 and 4 cases contained both subtypes. Four cases could not be typed. These findings suggest that in AILD, as in AIDS-associated lymphomas and lymphomas of the lethal midline granuloma type, subtype 2 of EBV may occur, perhaps in relation toan immunodysfunction developing progressively in these patients. (C) 1993 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 10:24:55