Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
AGE-DEPENDENCE OF A 6-HYDROXYDOPAMINE LESION ON SKF 38393-CHLOROPHENYLPIPERAZINE-INDUCED AND M-CHLOROPHENYLPIPERAZINE-INDUCED ORAL ACTIVITYRESPONSES OF RATS
Autore:
KOSTRZEWA RM; BRUS R; PERRY KW; FULLER RW;
Indirizzi:
E TENNESSEE STATE UNIV,JAMES H QUILLEN COLL MED,DEPT PHARMACOL JOHNSON CITY TN 37614 L WARYNSKI SILESIAN MED ACAD,DEPT PHARMACOL PL-41808 ZABRZE POLAND ELI LILLY & CO,LILLY RES LAB,LILLY CORP CTR INDIANAPOLIS IN 46285
Titolo Testata:
Developmental brain research
fascicolo: 1, volume: 76, anno: 1993,
pagine: 87 - 93
SICI:
0165-3806(1993)76:1<87:AOA6LO>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEONATAL 6-OHDA-LESIONED RATS; D-1 DOPAMINE-RECEPTORS; BEHAVIORAL-RESPONSES; RECOGNITION SITES; D1 RECEPTORS; AGONIST; BINDING; ANTAGONIST; D1-DOPAMINE; INDUCTION;
Keywords:
DOPAMINE; 5-HYDROXYTRYPTAMINE; ORAL ACTIVITY; SUPERSENSITIVITY; ONTOGENY; 6-HYDROXYDOPAMINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
R.M. Kostrzewa et al., "AGE-DEPENDENCE OF A 6-HYDROXYDOPAMINE LESION ON SKF 38393-CHLOROPHENYLPIPERAZINE-INDUCED AND M-CHLOROPHENYLPIPERAZINE-INDUCED ORAL ACTIVITYRESPONSES OF RATS", Developmental brain research, 76(1), 1993, pp. 87-93

Abstract

Neonatal 6-hydroxydopamine (6-OHDA) treatment is associated with destruction of dopamine (DA) fibers and subsequent sprouting of serotonin (5-HT) fibers in the striatum of rats. Enhanced oral activity responses to SKF 38393 and m-chlorophenylpiperazine (m-CPP), respective agonists for the DA D1 receptor complex and 5-HT2C receptor complex, ensue. To study the ontogenetic nature of this effect, rats were treated at birth, 3 days, 7 days, 10 days or 14 days with 6-OHDA-HBr (200 mug i.c.v.; salt form), following desipramine-HCl pretreatment (20 mg/kg i.p.,1 h; base form). Another group of rats was treated at 35 days and again at 42 days with 6-OHDA-HBr (300 mug i.c.v.), following desipramine-HCl (20 mg/kg i.p., 1 h) and pargyline-HCl (50 mg/kg i.p., 30 min). Inrats treated from birth to 10 days, 6-OHDA reduced striatal DA content at 5 months by greater-than-or-equal-to 94%. Striatal 5-HT content was elevated by 28% to 51%, but only in rats treated with 6-OHDA at 7 days from birth or earlier. An enhanced oral activity response to SKF 38393-HCl (0.03 to 1.0 mg/kg i.p.) was absent in rats treated 7 days orlater, and the change in SKF 38393 effect was correlated with a change in striatal DA content. An enhanced response to m-CPP . 2HCl (0.3 to6.0 mg/kg i.p.) was absent after treatment at 14 or 35 days, when striatal DA content was reduced only 44% to 63% and 5-HT content was not changed. Loss of the enhanced m-CPP response was not directly correlated with the magnitude of change in striatal content of either DA OT 5-HT. The findings indicate that SKF 38393 and m-CPP-enhanced oral activity responses are dependent on the age at which 6-OHDA is administeredto rats, and that the enhanced response to m-CPP can persist when there is no enhanced response to SKF 38393.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 16:09:33