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Titolo:
THE SINGLE-SUBJECT RANDOMIZED TRIAL - A USEFUL CLINICAL TOOL FOR ASSESSING THERAPEUTIC EFFICACY IN PEDIATRIC PRACTICE
Autore:
LANGER JC; WINTHROP AL; ISSENMAN RM;
Indirizzi:
ST LOUIS CHILDRENS HOSP,DIV PEDIAT SURG,ROOM 5W12,400 S KINGSHIGHWAY ST LOUIS MO 63110 MCMASTER UNIV,DEPT SURG HAMILTON L8S 4L8 ONTARIO CANADA MCMASTER UNIV,DEPT PEDIAT HAMILTON L8S 4L8 ONTARIO CANADA
Titolo Testata:
Clinical pediatrics
fascicolo: 11, volume: 32, anno: 1993,
pagine: 654 - 657
SICI:
0009-9228(1993)32:11<654:TSRT-A>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDIVIDUAL PATIENTS; CISAPRIDE; REFLUX; EXPERIENCE; CHILDREN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
J.C. Langer et al., "THE SINGLE-SUBJECT RANDOMIZED TRIAL - A USEFUL CLINICAL TOOL FOR ASSESSING THERAPEUTIC EFFICACY IN PEDIATRIC PRACTICE", Clinical pediatrics, 32(11), 1993, pp. 654-657

Abstract

The purpose of a single-subject randomized trial is to assess objectively the efficacy of a specific therapeutic intervention in an individual patient. Treatment is randomly alternated with placebo over a number of study periods. Specific outcome measures are recorded blindly and later compared via paired statistical analysis. Single-subject trials have long been successfully performed in adults, but rarely in children. We present single-subject trials of two pediatric patients done to assess the effect of cisapride on symptoms arising from gastroesophageal reflux. In the first patient, the drug affected neither vomiting nor gagging, although stool frequency increased. Since the symptoms ofconcern were unaffected, cisapride was discontinued. In the second patient, use of cisapride led to a significant decrease in vomiting and wheezing; the drug was therefore incorporated into the therapeutic regimen. Single-subject randomized trials are inexpensive and simple and can be used by the family physician, pediatrician, or pediatric surgeon in daily practice. They permit the rational use of effective therapyand the abandonment of ineffective measures.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 13:35:39