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Titolo:
DEVELOPMENT OF TOLERANCE AFTER HAPLOCOMPATIBLE T-DEPLETED BONE-MARROWTRANSPLANTATION
Autore:
MERINO A; DROR Y; BENKERROU M; COLOMBE BW; COWAN MJ;
Indirizzi:
UNIV CALIF SAN FRANCISCO,DEPT PEDIAT,BONE MARROW TRANSPLANT PROGRAM,505 PARNASSUS AV SAN FRANCISCO CA 94143 UNIV CALIF SAN FRANCISCO,DEPT PEDIAT,BONE MARROW TRANSPLANT PROGRAM,505 PARNASSUS AV SAN FRANCISCO CA 94143 UNIV CALIF SAN FRANCISCO,DEPT SURG,IMMUNOGENET & TRANSPLANTAT LAB SANFRANCISCO CA 94143 HOSP CLIN BARCELONA,POSTGRAD SCH HAEMATOL FARRERAS VALENTI BARCELONA SPAIN
Titolo Testata:
Bone marrow transplantation
fascicolo: 5, volume: 12, anno: 1993,
pagine: 483 - 488
SICI:
0268-3369(1993)12:5<483:DOTAHT>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEVERE COMBINED IMMUNODEFICIENCY; SOYBEAN AGGLUTININ; SELF-TOLERANCE; CLONAL ANERGY; HOST DISEASE; CELLS; THYMUS; REACTIVITY; CHIMERISM; RESPONSES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
A. Merino et al., "DEVELOPMENT OF TOLERANCE AFTER HAPLOCOMPATIBLE T-DEPLETED BONE-MARROWTRANSPLANTATION", Bone marrow transplantation, 12(5), 1993, pp. 483-488

Abstract

We evaluated proliferative responses in mixed lymphocyte cultures (MLC) following bone marrow transplantation (BMT) in 14 recipients of T cell-depleted haplocompatible parental marrow: 11 for the treatment of severe combined immunodeficiency (SCID), 2 for leukemia and 1 for Wiskott-Aldrich syndrome (WAS). We compared the results obtained in 9 SCIDpatients and 1 WAS patient with split chimerism (T cells of donor origin, B cells and monocytes of recipient origin) to 4 patients (2 SCID and 2 leukemias) who were full chimeras (T, B and monocytes of donor origin). In the full chimeras, as with the fresh donor PBMC, fresh donor T cells did not proliferate in the MLC to recipient non-T cells (E-). In this group there were no differences (p > 0.2) between the responses of engrafted T and fresh donor T to recipient E- cells. We found tolerance of engrafted donor T celts to residual mismatched T cell-depleted (E-) recipient cells in the split chimera group. In this group the engrafted T cells had low or no responses in MLC to HLA mismatched E- host cells compared with fresh donor cells (p < 0.001). In 3 of 8 split chimera patients that we tested the addition of small numbers (5000-10 000) of freshly isolated donor T cells, irradiated or not, resulted in a two fold increase in the engrafted T cell response to recipient E- cells. In contrast, in 3 of 3 full chimeras tested, the addition of fresh donor T cells had no demonstrable effect on the response of engrafted T cells to recipient E-. The proportion of T cell subsets in the responding cell populations was similar to that seen in normal control MLC. Finally, in one patient there was no evidence for a suppression mechanism of tolerance. These results are consistent with either deletion of a T cell subpopulation responsive to recipient alloantigensand/or an anergy model in which engrafted T cells do not respond to class II MHC antigens because they fail to produce a necessary cytokine.

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Documento generato il 07/07/20 alle ore 22:13:27