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Titolo:
INVOLVEMENT OF THE CENTRAL-NERVOUS-SYSTEM IN THE SALIVARY SECRETION INDUCED BY PILOCARPINE IN RATS
Autore:
RENZI A; COLOMBARI E; FILHO TRM; SILVEIRA JEN; SAAD WA; CAMARGO LAA; DELUCA LA; DEROBIO JG; MENANI JV;
Indirizzi:
PAULISTA STATE UNIV,SCH DENT,DEPT PHYSIOL,1680 HUMAITA STR ARARAQUARA14801903 SP BRAZIL CAMPINAS STATE UNIV,SCH DENT,DEPT PHYSIOL SCI PIRACICABA SP BRAZIL
Titolo Testata:
Journal of dental research
fascicolo: 11, volume: 72, anno: 1993,
pagine: 1481 - 1484
SICI:
0022-0345(1993)72:11<1481:IOTCIT>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUBMANDIBULAR GLANDS; STIMULATION; RESPONSES; LESION; AV3V;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
A. Renzi et al., "INVOLVEMENT OF THE CENTRAL-NERVOUS-SYSTEM IN THE SALIVARY SECRETION INDUCED BY PILOCARPINE IN RATS", Journal of dental research, 72(11), 1993, pp. 1481-1484

Abstract

The effect in rats of an anteroventral third ventricle (AV3V) electrolytic lesion on salivary secretion induced by intraperitoneal (i.p.) or intracerebroventricular (i.c.v.) injection of a cholinergic agonist (pilocarpine) was investigated. Sham- or AV3V-lesioned rats anesthetized with urethane and with a stainless steel cannula implanted into thelateral ventricle (LV) were used. The amount of salivary secretion was studied over a seven-minute period after i.c.v. or i.p. injection ofpilocarpine. In sham-operated rats, i.p. injection of pilocarpine (1 mg/kg b.w. ) (after 6 h, 2, 7, and 15 days) produced salivary secretion(486 +/- 21, 778 +/- 85, 630 +/- 50, and 560 +/- 55 mg/7 min, respectively). This effect was reduced 6 h, 2, and 7 days after an AV3V lesion (142 +/- 22, 113 +/- 32, and 290 +/- 62 mg/7 min, respectively), butnot 15 days after an AV3V lesion (516 +/- 19 mg/7 min). I.c.v. injection of pilocarpine (120 mug in 1 muL), in sham-operated rats after 6 h, 2, 7, and 15 days also produced salivary secretion (443 +/- 20, 417 /- 81, 496 +/- 14, and 427 +/- 47 mg/7 min, respectively). The effects of i.c.v. pilocarpine were also reduced 6 h, 2, and 7 days after an AV3V lesion (143 +/- 19, 273 +/- 14, and 322 +/- 17 mg/7 min, respectively), but not after 15 days (450 +/- 28 mg/7 min). The results demonstrate that the central nervous system, and particularly the AV3V region, is important for the effect of pilocarpine on salivary secretion inrats. Moreover, they suggest that activation of central pathways may play an important part in the salivary secretion to peripheral pilocarpine in rats.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 16:44:13