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Titolo:
A MODEL OF THE INSTANTANEOUS PRESSURE-VELOCITY RELATIONSHIPS OF THE NEONATAL CEREBRAL-CIRCULATION
Autore:
PANERAI RB; COUGHTREY H; RENNIE JM; EVANS DH;
Indirizzi:
UNIV LEICESTER,FAC MED,DIV MED PHYS LEICESTER W YORKSHIRE ENGLAND ROSIE MATERN HOSP CAMBRIDGE CB2 2SW CAMBS ENGLAND
Titolo Testata:
Physiological measurement
fascicolo: 4, volume: 14, anno: 1993,
pagine: 411 - 418
SICI:
0967-3334(1993)14:4<411:AMOTIP>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-FLOW VELOCITY; DOPPLER ULTRASOUND; MAXIMUM VELOCITY; ARTERIES; VARIABILITY; RECORDINGS; HEMORRHAGE; INFANTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
R.B. Panerai et al., "A MODEL OF THE INSTANTANEOUS PRESSURE-VELOCITY RELATIONSHIPS OF THE NEONATAL CEREBRAL-CIRCULATION", Physiological measurement, 14(4), 1993, pp. 411-418

Abstract

The instantaneous relationship between arterial blood pressure (BP) and cerebral blood flow velocity (CBFV), measured the Doppler ultrasound in the anterior cerebral artery, is represented by a vascular waterfall model comprising vascular resistance, compliance, and critical closing pressure. One min recordings obtained from 61 low birth weight newborns were fitted to the model using a least-squares procedure with correction for the time delay between the BP and CBFV signals. A sensitivity analysis was performed to study the effects of low-pass filtering (LPF), cutoff frequency, and noise on the estimated parameters of the model. Results indicate excellent fitting of the model (F-test, p < 0.0001) when the BP and CBFV signals are LPF at 7.5 Hz. Reconstructed CBFV waveforms using the BP signal and the model parameters have a mean correlation coefficient of 0.94 with the measured flow velocity tracing (N = 232 epochs). The model developed can be useful for interpreting clinical findings and as a framework for research into cerebral autoregulation.

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Documento generato il 30/11/20 alle ore 02:52:05