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Titolo:
MULTIPLE RISK FACTOR INTERVENTION TRIAL - RISK FACTOR CHANGES AND MORTALITY RESULTS (REPRINTED FROM JAMA, VOL 248, PG 1465-1477, 1982)
Autore:
PAUL O; ARNOLD CB; MANDRIOTA R; AMES RP; EISENBACH JR; BOHN E; THOMAS HE; KANNEL WB; ROTONDO R; CONNORS J; BRAND FN; SMITH LK; PRISCO MT; GREENE P; KEZDI P; STANLEY EL; BLACK WL; ERNST FA; CASE EJ; BENTLEY V; COVERT D; LUCIUS M; PARIS F; SEMMETT R; SKOTKO L; CHRISTAKIS G; BURR JM; GERACE TA; WILCOX ME; BRAMSON D; BENEZRA J; WEDDLE J; KAYE J; PADRON M; RAUTAHARJU PM; WOLF H; BENFARI RC; MCINTYRE KM; DANIELSON E; OCKENE J; KOUSCHHOWARD D; BALDWIN AD; WILD JB; GREENLICK M; GROVER J; LAMB S; BAILEY J; DYER J; BROKOP B; STEVENS V; BAILEY G; HOLMES W; PICKERING JE; ALLAIRE J; DUFFY EL; FELLON D; FEINSTEIN B; HUTCHINS D; RUBEL G; COOPER GR; BAYSE DD; MILLER DT; HAINLINE A; KUCHMAK M; WIEBE DA; WINN CL; TAYLOR L; BOTERO BL; GILL JB; LASSER NL; HYMOWITZ N; MEZEY KC; MUNVES B; PARELL E; BURGIO S; LASSER V; JOHNSON B; JEFFREY S; RICE E; STAMLER J; MOSS D; PERSKY V; ROBINSON E; VANHORN L; SHANNON K; MEYERS D; COHEN L; MORGAN J; GRUNDMANN G; VESTAL TD; HUANG B; BERKSON DM; LAUGER G; GRUJIC S; OBRADOVIC D; PARDO E; DUA S; MCGOWAN S; BILLINGS J; HULLEY SB; SMITH WM; SYME SL; COHEN R; DZVONIK L; ROOS L; KAHN M; WIDDOWSON GM; WILLIAMS GZ; KUEHNEMAN ML; SCHOENBERGER JA; SCHOENENBERGER JC; SHEKELLE RB; NERI GS; DOLECEK T; BETZ E; SKWERES L; OPPENHEIMER F; GERNHOFER N; HARDY GG; MCGILL E; HALL Y; WRIGHT NH; KOPEL SA; SUCKERMAN KR; SCHORIN M; SIMON N; COHEN JD; BUNKERS E; RONCHETTO B; GRODSKY E; FRESSOLA A; DANIELGENTRY J; TREIMAN R; SULLIVAN W; SCHNAPER HW; HUGHES GH; OBERMAN A; HILL CC; ALLEN R; BRAGG C; STOKES S; JOHNSON P; BORHANI NO; SUGARS C; KIRKPATRICK K; LEE M; DEBOURELANDO S; LABAW F; TURNERTUCKER J; SHERWIN RW; SEXTON MS; CUSACK NE; DEBARROS QTF; DISCHINGER PC; SPIZLER JF; HEINER JD; PILKINGTON MB; SCANLON BL; GRIMM RH; MITTELMARK M; CROW RS; BLACKBURN H; JACOBS D; RAINS D; MCDONALD M; LENZ K; PRINEAS RJ; CROW RC; BUZZARD IM; GRAMBSCH PV; WENZ J; KJELSBERG MO; BARTSCH GE; NEATON JD; AUS BM; BENDICKSON J; BROSTE SK; CONNETT JE; DUCHENE AG; DURKIN DA; GORDER DL; GRANDITS GA; HULTGREN DH; KNICKERBOCKER A; RASMUSSEN WL; SVENDSEN KH; WILLE L; KULLER LH; MCDONALD R; CAGGIULA A; FALVOGERARD L; MEILAHN E; MILAS NC; RUSSELL R; HORBIAK J; ALMAN M; SOUTHWICK K; MOYER R; GAHAGAN E; GIESE WK; MARTIN JF; KEITH JA; HARRISON HH; MATHIS DE; BROWN CK; FISHMAN E; WAMPLER L; NEWMARK G; ROSENFIELD F; SIDDIQUI S; SAVAGE W; BRADFORD A; INSULL W; FARQUHAR JW; JENKINS CD; RAPAPORT E; THOMPSON DJ; TYROLER HA; WILLIS PW; FRIEDEWALD WT; ZUKEL W; DOYLE JT; BURCHELL HB; YU PN; WILLIS PW; FURBERG CD; CUTLER JA; ZUKEL WJ; PASSAMANI ER; KAELBER CT; FARRAND ME; TILLOTSON JL; VERTER JI; WU MC; GORDON T; HALPERIN M; MCGEE DL; BLASZKOWSKI TP; EBERLEIN KA; HARRIS CE; DERN PL; FRIEDMAN LM; MAY GS; VARGOSKO AJ;
Indirizzi:
UNIV MINNESOTA,SCH PUBL HLTH,DIV BIOMETRY,MRFIT COORDINATING CTR MINNEAPOLIS MN 55414 UNIV MINNESOTA,SCH PUBL HLTH,DIV BIOMETRY,MRFIT COORDINATING CTR MINNEAPOLIS MN 55414
Titolo Testata:
JAMA, the journal of the American Medical Association
fascicolo: 7, volume: 277, anno: 1997,
pagine: 582 - 594
SICI:
0098-7484(1997)277:7<582:MRFIT->2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
MRFIT; SMOKING; LIPIDS;
Tipo documento:
Reprint
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
O. Paul et al., "MULTIPLE RISK FACTOR INTERVENTION TRIAL - RISK FACTOR CHANGES AND MORTALITY RESULTS (REPRINTED FROM JAMA, VOL 248, PG 1465-1477, 1982)", JAMA, the journal of the American Medical Association, 277(7), 1997, pp. 582-594

Abstract

The Multiple Risk Factor Intervention Trial was a randomized primary prevention trial to test the effect of a multifactor intervention program on mortality from coronary heart disease (CHD) in 12,866 high-riskmen aged 35 to 57 years. Men were randomly assigned either to a special intervention (SI) program consisting of stepped-care treatment for hypertension, counseling for cigarette smoking, and dietary advice forlowering blood cholesterol levels, or to their usual sources of health care in the community (UC). Over an average follow-up period of seven years, risk factor levels declined in both groups but to a greater degree for the SI men. Mortality from CHD was 17.9 deaths per 1,000 in the SI group and 19.3 per 1,000 In the UC group, a statistically nonsignificant difference of 7.1% (90% confidence interval, -15% to 25%). Total mortality rates were 41.2 per 1,000 (SI) and 40.4 per 1,000 (UC). Three possible explanations for these findings are considered: (1) the overall intervention program, under these circumstances, does not affect CHD mortality; (2) the intervention used does affect CHD mortality, but the benefit was not observed in this trial of seven years' average duration, with lower-than-expected mortality and with considerablerisk factor change in the UC group; and (3) measures to reduce cigarette smoking and to lower blood cholesterol levels may have reduced CHDmortality within subgroups of the SI cohort, with a possibly unfavorable response to antihypertensive drug therapy in certain but not all hypertensive subjects. This last possibility was considered most likely, needs further investigation, and lends support to some preventive measures while requiring reassessment of others.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 03:37:02