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Titolo:
EVOLUTION OF THE BIOARTIFICIAL LIVER - THE NEED FOR RANDOMIZED CLINICAL-TRIALS
Autore:
NYBERG SL; PESHWA MV; PAYNE WD; HU WS; CERRA FB;
Indirizzi:
406 HARVARD ST SE,BOX 42 UMHC MINNEAPOLIS MN 55455 UNIV MINNESOTA,DEPT SURG MINNEAPOLIS MN 55455 UNIV MINNESOTA,DEPT CHEM ENGN & MAT SCI MINNEAPOLIS MN 55455
Titolo Testata:
The American journal of surgery
fascicolo: 5, volume: 166, anno: 1993,
pagine: 512 - 521
SICI:
0002-9610(1993)166:5<512:EOTBL->2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
FULMINANT HEPATIC-FAILURE; HOLLOW-FIBER MEMBRANES; MICROCARRIER-ATTACHED HEPATOCYTES; ADULT-RAT HEPATOCYTES; CHARCOAL HEMOPERFUSION; ARTIFICIAL LIVER; MICROENCAPSULATED HEPATOCYTES; ASSIST DEVICE; GUNN-RATS; BIOSILON MICROCARRIERS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
106
Recensione:
Indirizzi per estratti:
Citazione:
S.L. Nyberg et al., "EVOLUTION OF THE BIOARTIFICIAL LIVER - THE NEED FOR RANDOMIZED CLINICAL-TRIALS", The American journal of surgery, 166(5), 1993, pp. 512-521

Abstract

The pursuit of a bioartificial liver is well documented in the literature. Early techniques of artificial liver support that have undergoneclinical testing included simple exchange transfusions, extracorporeal xenogeneic or allogeneic liver perfusion, cross-circulation, hemodialysis, charcoal hemoperfusion, and plasmapheresis with plasma exchange. These techniques failed because they were unable to adequately support those hepatic functions essential for survival and because they lacked a back-up therapy, such as liver transplantation, for irreversibleforms of liver disease. The concept evolved that hepatic functions essential for survival would be best performed by hepatocytes in an apparatus that allowed sustained or repetitive application. The best results have been achieved with bioartificial liver technologies that employ hepatocytes as implantable systems or extracorporeal devices. Implantable bioartificial liver systems include hepatocytes that have been on coated microcarrier beads, within microencapsulated gel droplets, within biodegradable polymeric substrates, or as spheroid hepatocyte aggregates. Extracorporeal systems include hepatocytes in suspension, on flat plates, and in hollow fiber bioreactors. Several extracorporeal systems have undergone extensive animal testing and are entering the early stages of human clinical trials. Randomized trials are needed to establish the value of bioartificial liver support in the treatment of patients with acute hepatic failure or as a bridge to liver transplantation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/21 alle ore 15:06:39