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Titolo:
NONCHOLINERGIC FUNCTIONS OF CHOLINESTERASES
Autore:
BALASUBRAMANIAN AS; BHANUMATHY CD;
Indirizzi:
CHRISTIAN MED COLL & HOSP,DEPT NEUROL SCI,NEUROCHEM LAB VELLORE 632004 INDIA
Titolo Testata:
The FASEB journal
fascicolo: 14, volume: 7, anno: 1993,
pagine: 1354 - 1358
SICI:
0892-6638(1993)7:14<1354:NFOC>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-SERUM PSEUDOCHOLINESTERASE; ALPHA-CHYMOTRYPSIN DIGESTION; ARYL ACYLAMIDASE ACTIVITIES; SERINE CARBOXYPEPTIDASE-II; TRYPSIN-LIKE; CHEMICAL MODIFICATION; TORPEDO-CALIFORNICA; PEPTIDASE ACTIVITY; BASAL GANGLIA; SUBSTANCE-P;
Keywords:
ACETYLCHOLINESTERASE; BUTYRYLCHOLINESTERASE; ARYL ACYLAMIDASE; METALLOCARBOXYPEPTIDASE; NEURAL CELL DIFFERENTIATION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
61
Recensione:
Indirizzi per estratti:
Citazione:
A.S. Balasubramanian e C.D. Bhanumathy, "NONCHOLINERGIC FUNCTIONS OF CHOLINESTERASES", The FASEB journal, 7(14), 1993, pp. 1354-1358

Abstract

Cholinesterases (acetylcholinesterase and butyrylcholinesterase) exhibit additional catalytic activities apart from their well-known actionin hydrolyzing choline esters. An amine-sensitive aryl acylamidase activity is exhibited by both acetyl- and butyrylcholinesterases. A metallocarboxypeptidase-like activity is found associated with both acetyl- and butyrylcholinesterases. The peptidase activity exhibited by butyrylcholinesterase was located in a 50-kDa COOH-terminal fragment. Acetylcholinesterase is implicated in noncholinergic functions in the substantia nigra. A relationship between tumorigenesis, cell differentiation, and cholinesterases has been speculated. The sequence similaritiesbetween different esterases, lipases, thyroglobulin, cell adhesion proteins, and cholinesterases would make it appear that cholinesterases are capable of exhibiting more than one biological activity and their functions are wider than what is hitherto known.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 16:30:20