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Titolo:
ENHANCEMENT OF MITOMYCIN-C CYTOTOXICITY BY COMBINATION WITH FLAVONE ACETIC-ACID IN A MURINE TUMOR
Autore:
PARKINS CS; DENEKAMP J; CHAPLIN DJ;
Indirizzi:
MT VERNON HOSP,CANC RES CAMPAIGN GRAY LAB,VASC TARGETING GRP,POB 100 NORTHWOOD HA6 2JR MIDDX ENGLAND
Titolo Testata:
Anticancer research
fascicolo: 5A, volume: 13, anno: 1993,
pagine: 1437 - 1442
SICI:
0250-7005(1993)13:5A<1437:EOMCBC>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYTOKINE GENE-EXPRESSION; RENAL-CANCER; BIOREDUCTIVE DRUGS; HYPOXIC CELLS; INDUCTION; MICE; NSC-347512; INVIVO; EMT6;
Keywords:
TUMOR ISCHEMIA; PH; FLAVONE ACETIC ACID; MITOMYCIN-C;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
C.S. Parkins et al., "ENHANCEMENT OF MITOMYCIN-C CYTOTOXICITY BY COMBINATION WITH FLAVONE ACETIC-ACID IN A MURINE TUMOR", Anticancer research, 13(5A), 1993, pp. 1437-1442

Abstract

The antitumour activity of a combination of Mitomycin C (MMC), a prototypical bioreductive agent, with the vascular occluding agent, flavone acetic acid (FAA), was examined in a murine tumour. Flavone acetic acid induced a long lived reduction of blood flow in the tumour therebyinducing hypoxia and cell death by ischaemia. Dose response curves for tumour cell survival and regrowth delay were constructed after each agent administered alone or when combined The greatest antitumour effect was measured when the two agents were administered simultaneously. The reduced tumour perfusion induced by the combination was not lower than that for FAA alone indicating that the greater in vivo effect wasnot due to enhancement of the vascular occluding effect of the FAA. The role of the tumour microenvironment in determing the MMC cytotoxicity was examined using in vitro incubations of MMC under controlled oxygenation and pH. MMC cytotoxicity was increased in hypoxia (enhancement ratio = 2.0) and also when extracellular pH was reduced from 7.4 to 6.4 (enhancement ratio = 1.5). Since the microenvironmental consequences of induced ischaemia are reductions in both oxygention and pH theseparameters are probably responsible in large part for the enhancementof cytotoxicity observed when MMC and FAA are combined.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 21:55:44