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Titolo:
AEROSOL BOLUS DISPERSION IN HEALTHY-SUBJECTS
Autore:
BRAND P; RIEGER C; SCHULZ H; BEINERT T; HEYDER J;
Indirizzi:
GSF FORSCHUNGSZENTRUM UMWELT & GESUNDHEIT,INST INHALAT BIOL,ROBERT KOCH ALLEE 6 D-82131 GAUTING GERMANY GSF FORSCHUNGSZENTRUM UMWELT & GESUNDHEIT,INST INHALAT BIOL OBERSCHLEISSHEIM GERMANY
Titolo Testata:
The European respiratory journal
fascicolo: 2, volume: 10, anno: 1997,
pagine: 460 - 467
SICI:
0903-1936(1997)10:2<460:ABDIH>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPIRATORY-TRACT; LUNG; VARIABILITY; CHILDREN;
Keywords:
AEROSOL BOLUS DISPERSION; CONVECTIVE GAS MIXING; FLOW RATE; HEALTHY SUBJECTS; LUNG INFLATION; VENTILATORY INHOMOGENEITIES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
P. Brand et al., "AEROSOL BOLUS DISPERSION IN HEALTHY-SUBJECTS", The European respiratory journal, 10(2), 1997, pp. 460-467

Abstract

Aerosol bolus dispersion is a physiological test of lungs, which usesmonodisperse submicron particles to measure intrapulmonary convectivegas mixing, In this study, aerosol bolus dispersion was measured in healthy subjects in order to assess reference values for possible clinical applications, to assess the reproducibility of these values, and to identify physical and physiological factors influencing aerosol bolus dispersion. Aerosol bolus dispersion was measured in 79 healthy subjects using 20 cm(3) aerosol boluses consisting of monodisperse di-2-ethylhexyl sebacate (DEHS) particles. The reproducibility of parameters characterizing the width of the exhaled bolus was of the same order asthat of parameters of the flow-volume curve (10%), Aerosol bolus dispersion mas independent of the level of lung inflation, and the slope of the relationship between flow rate and dispersion was on average notsignificantly different from zero (range 100-700 cm(3) . s(-1)). Multiple linear regression showed that aerosol bolus dispersion increased with increasing total lung capacity of the subject. We conclude that differences in total lung capacity between individuals should be taken into account when using measures of aerosol bolus dispersion for possible clinical applications.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 15:16:50