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Titolo:
EFFECTS OF CCK(8) AND OF THE CCK(B)-SELECTIVE AGONIST BC264 ON EXTRACELLULAR DOPAMINE CONTENT IN THE ANTERIOR AND POSTERIOR NUCLEUS-ACCUMBENS - A MICRODIALYSIS STUDY IN FREELY MOVING RATS
Autore:
LADURELLE N; KELLER G; ROQUES BP; DAUGE V;
Indirizzi:
UNIV PARIS 05,FAC SCI PHARMACEUT & BIOL,DEPT PHARMOCHIM MOLEC & STRUCT,CNRS F-75270 PARIS 06 FRANCE UNIV PARIS 05,FAC SCI PHARMACEUT & BIOL,DEPT PHARMOCHIM MOLEC & STRUCT,CNRS F-75270 PARIS 06 FRANCE UNIV PARIS 05,FAC SCI PHARMACEUT & BIOL,DEPT CHIM MINERALE STRUCT,CNRS,URA 200 F-75270 PARIS 06 FRANCE
Titolo Testata:
Brain research
fascicolo: 1-2, volume: 628, anno: 1993,
pagine: 254 - 262
SICI:
0006-8993(1993)628:1-2<254:EOCAOT>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED LOCOMOTOR-ACTIVITY; CHOLECYSTOKININ OCTAPEPTIDE; RECEPTOR ANTAGONISTS; ALTERNATION BEHAVIOR; ENDOGENOUS DOPAMINE; VENTRAL STRIATUM; INVIVO RELEASE; CAUDAL PART; NEURONS; BRAIN;
Keywords:
NUCLEUS ACCUMBENS; CHOLECYSTOKININ; LOCAL PERFUSION; DOPAMINE RELEASE; MICRODIALYSIS; FREELY MOVING RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
48
Recensione:
Indirizzi per estratti:
Citazione:
N. Ladurelle et al., "EFFECTS OF CCK(8) AND OF THE CCK(B)-SELECTIVE AGONIST BC264 ON EXTRACELLULAR DOPAMINE CONTENT IN THE ANTERIOR AND POSTERIOR NUCLEUS-ACCUMBENS - A MICRODIALYSIS STUDY IN FREELY MOVING RATS", Brain research, 628(1-2), 1993, pp. 254-262

Abstract

The effects of the local administration of cholecystokinin octapeptide (CCK8) in the posterior nucleus accumbens (N. Acc.) and of BC264 (a selective CCK(B) agonist) in the anterior N. Acc. on dopamine (DA) neurotransmission were studied in awake rats. Microdialysis was used to quantify the extracellular contents of DA and its two metabolites, 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA). In theposterior N. Acc., a perfusion of 10(-5) M CCK, for 40 min (i.e. 25 pmol) increased the extracellular levels of DA, DOPAC and HVA. In contrast, 10(-4) M BC264 perfused for 40 min (i.e. 350 pmol) into the anterior N. Acc. reduced extracellular DA but did not modify DOPAC and HVA levels. These findings suggest that the CCK-DA interactions are different in various regions of the N. Acc. and emphasize the functional heterogeneity of the N. Acc., issuing in part from its particular DA innervation (mixed CCK-DA terminals only in the posterior region) but alsofrom the distribution of the CCK fibers and binding sites in this nucleus. This microdialysis study, using perfusions of CCK compounds in the N. Acc. of freely moving rats, shows that the CCK system might playan important regulatory role in limbic DA function.

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Documento generato il 19/01/20 alle ore 20:49:36