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Titolo:
IMMUNE RECONSTITUTION WITH DONOR-DERIVED MEMORY EFFECTOR T-CELLS AFTER ORTHOTOPIC LIVER-TRANSPLANTATION/
Autore:
COLLINS RH; SACKLER M; PITCHER CJ; WALDROP SL; KLINTMALM GB; JENKINS R; PICKER LJ;
Indirizzi:
UNIV TEXAS,SW MED CTR,DEPT PATHOL,LAB EXPT PATHOL,5323 HARRY HINES BLVD DALLAS TX 75235 UNIV TEXAS,SW MED CTR,DEPT PATHOL,LAB EXPT PATHOL DALLAS TX 75235 UNIV TEXAS,SW MED CTR,DEPT PATHOL,CLIN IMMUNOL LAB DALLAS TX 75235 UNIV TEXAS,SW MED CTR,HAROLD C SIMMONS ARTHRIT RES CTR DALLAS TX 75235 BAYLOR UNIV,MED CTR,BONE MARROW & SOLID ORGAN TRANSPLANTAT SERV DALLAS TX 00000
Titolo Testata:
Experimental hematology
fascicolo: 2, volume: 25, anno: 1997,
pagine: 147 - 159
SICI:
0301-472X(1997)25:2<147:IRWDME>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE-MARROW TRANSPLANTATION; VERSUS-HOST DISEASE; LYMPHOCYTES-T; PERIPHERAL-BLOOD; MEMORY; EXPRESSION; CD4+; SUBSET; DIFFERENTIATION; ALLORECOGNITION;
Keywords:
TRANSPLANTATION; IMMUNE RECONSTITUTION; MEMORY/EFFECTOR T CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
R.H. Collins et al., "IMMUNE RECONSTITUTION WITH DONOR-DERIVED MEMORY EFFECTOR T-CELLS AFTER ORTHOTOPIC LIVER-TRANSPLANTATION/", Experimental hematology, 25(2), 1997, pp. 147-159

Abstract

Therapeutic hematopoietic stem cell transplantation has made great strides in recent years, providing curative therapy for many previously untreatable diseases. Nevertheless, the applicability and effectiveness of this procedure continues to be restricted by adverse immunoregulatory states, including graft rejection, graft vs. host disease (GvHD),and/or persistent immunodeficiency. Here, we provide evidence that long-term hematopoietic stem cell transplantation across major histocompatibility complex (MHC) barriers is possible in the human with limitedadverse sequelae. We observed the rapid, complete, and stable replacement of recipient hematopoiesis and B lymphopoiesis with donor-derivedcells approximately 6 weeks following orthotopic liver transplantation for hemochromatosis. Long-term T lineage reconstitution also occurred, but most intriguingly, derived almost exclusively from expansion ofmature, memory/effector T cells from the transplanted liver. Althoughdemonstrating both functional and molecular evidence of a simplified T cell receptor (TCR) repertoire and unable to become sensitized to ''new'' antigens (Ag), this patient demonstrated long-term clinical immunocompetence. Moreover, the transplanted T cells were effectively tolerant to host tissues as the patient did not manifest clinically significant GVHD off immunosuppressive therapy. These observations suggest that isolated memory/effector T cell populations have the potential of promoting stem cell engraftment in an allogeneic host without persistent GvHD, and to provide sufficient immune reconstitution to provide the recipient with long-term immune homeostasis.

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Documento generato il 23/09/20 alle ore 12:35:42