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Titolo:
A ROLE FOR ADENOSINE IN METABOLIC DEPRESSION IN THE MARINE INVERTEBRATE SIPUNCULUS-NUDUS
Autore:
REIPSCHLAGER A; NILSSON GE; PORTNER HO;
Indirizzi:
ALFRED WEGENER INST POLAR & MARINE RES,POSTFACH 120161 D-27515 BREMERHAVEN GERMANY ALFRED WEGENER INST POLAR & MARINE RES D-27515 BREMERHAVEN GERMANY UPPSALA UNIV,DEPT LIMNOL,VERTEBRATE PHYSIOL & BEHAV UNIT S-75236 UPPSALA SWEDEN UNIV OSLO,DIV GEN PHYSIOL N-0316 OSLO NORWAY
Titolo Testata:
American journal of physiology. Regulatory, integrative and comparative physiology
fascicolo: 1, volume: 41, anno: 1997,
pagine: 350 - 356
SICI:
0363-6119(1997)41:1<350:ARFAIM>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACID-BASE STATUS; CRUCIAN CARP; ANOXIA-TOLERANT; TURTLE BRAIN; NEUROTRANSMITTERS; OXYCONFORMER; HEPATOCYTES; MECHANISM; ISCHEMIA; SURVIVAL;
Keywords:
MONOAMINE TRANSMITTERS; AMINO ACID TRANSMITTERS; ANOXIA; HYPERCAPNIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
A. Reipschlager et al., "A ROLE FOR ADENOSINE IN METABOLIC DEPRESSION IN THE MARINE INVERTEBRATE SIPUNCULUS-NUDUS", American journal of physiology. Regulatory, integrative and comparative physiology, 41(1), 1997, pp. 350-356

Abstract

Involvement of neurotransmitters in metabolic depression under hypoxia and hypercapnia was examined in Sipunculus nudus. Concentration changes of several putative neurotransmitters in nervous tissue during anoxic or hypercapnic exposure or during combined anoxia and hypercapnia were determined. Among amino acids (gamma-aminobutyric acid, glutamate, glycine, taurine, serine, and aspartate) and monoamines (serotonin, dopamine, and norepinephrine), some changes were significant, but nonewere consistent with metabolic depression under all experimental conditions applied. Only the neuromodulator adenosine displayed concentration changes in accordance with metabolic depression under all experimental conditions. Levels increased during anoxia, during hypercapnia, and to an even greater extent during anoxic hypercapnia. Adenosine infusions into coelomic fluid via an indwelling catheter induced a significant depression of the normocapnic rate of O-2 consumption from 0.36 +/- 0.04 to a minimum of 0.24 +/- 0.02 (SE) mu mol . g(-1). h(-1) after90 min (n = 6). Application of the adenosine antagonist theophylline caused a transient rise in O-2 consumption 30 min after infusion during hypercapnia but not during normocapnia. Effects of adenosine and theophylline were observed in intact individuals but not in isolated bodywall musculature. The results provide evidence for a role of adenosine in inducing metabolic depression in S. nudus, probably through the established effects of decreasing neuronal excitability and neurotransmitter release. In consideration of our previous finding that metabolicdepression in isolated body wall musculature was elicited by extracellular acidosis, it is concluded that central and cellular mechanisms combine to contribute to the overall reduction in metabolic rate in S. nudus.

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Documento generato il 25/11/20 alle ore 15:48:04