Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
CCK IS INVOLVED IN BOTH PERIPHERAL AND CENTRAL MECHANISMS CONTROLLINGFOOD-INTAKE IN CHICKENS
Autore:
RODRIGUEZSINOVAS A; FERNANDEZ E; MANTECA X; FERNANDEZ AG; GONALONS E;
Indirizzi:
UNIV AUTONOMA BARCELONA,FAC VET,DEPT CELL BIOL & PHYSIOL,PHYSIOL UNITBELLATERRA 08193 BARCELONA SPAIN UNIV AUTONOMA BARCELONA,FAC VET,DEPT CELL BIOL & PHYSIOL,PHYSIOL UNITBELLATERRA 08193 BARCELONA SPAIN
Titolo Testata:
American journal of physiology. Regulatory, integrative and comparative physiology
fascicolo: 1, volume: 41, anno: 1997,
pagine: 334 - 340
SICI:
0363-6119(1997)41:1<334:CIIIBP>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
GASTRIN-RELEASING PEPTIDE; CHOLECYSTOKININ RECEPTORS; BRAIN CHOLECYSTOKININ; B RECEPTORS; SATIETY; ANTAGONISTS; RATS; OCTAPEPTIDE; INJECTIONS; SECRETION;
Keywords:
CHOLECYSTOKININ; L-364,718; L-365,260; SATIETY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
A. Rodriguezsinovas et al., "CCK IS INVOLVED IN BOTH PERIPHERAL AND CENTRAL MECHANISMS CONTROLLINGFOOD-INTAKE IN CHICKENS", American journal of physiology. Regulatory, integrative and comparative physiology, 41(1), 1997, pp. 334-340

Abstract

The aim of this work was to study the involvement of cholecystokinin (CCK) in the control of food intake in chickens. The following aspectswere studied: 1) the effects of intravenous and intracerebroventricular sulfated octapeptide of CCK (CCK-8s) on voluntary food intake; 2) the effects of two CCK-receptor antagonists, L-365,260 and L-364,718, on food intake; and 3) the ability of such drugs to block the effects of CCK-8s on food intake in the chicken. Intravenous and intracerebroventricular CCK-8s caused a decrease in food intake. Intraperitoneal L-365,260, a CCK-receptor antagonist with low affinity for the two CCK receptors described in the chicken, increases food intake. Intracerebroventricular L-364,718, a drug that has high affinity for the chicken central CCK-receptor type, increased food intake. The effect of intravenous CCK-8s on food intake was not blocked by L-364,718 or L-365,260, whereas that of intracerebroventricular CCK-8s was blocked by intracerebroventricular L-364,718. It is concluded that central endogenous CCK plays a role in the control of food intake, which is dependent on central CCK-receptor type; nevertheless, peripheral CCK also decreases food intake acting on the peripheral CCK-receptor type. The fact that intracerebroventricular L-364,718 is able to increase food intake is related to its high affinity for the central CCK-receptor type of this species. Finally, three different speculations that might explain the fact that intraperitoneal L-365,260 increases food intake are discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 19:24:40