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Titolo:
ACUTE AND CHRONIC EFFECTS OF ALLERGIC AIRWAY INFLAMMATION ON PULMONARY NITRIC-OXIDE PRODUCTION
Autore:
MEHTA S; LILLY CM; ROLLENHAGEN JE; HALEY KJ; ASANO K; DRAZEN JM;
Indirizzi:
HARVARD UNIV,SCH MED,BRIGHAM & WOMENS HOSP,DIV PULM,75 FRANCIS ST BOSTON MA 02115 HARVARD UNIV,SCH MED,BRIGHAM & WOMENS HOSP,DIV PULM BOSTON MA 02115
Titolo Testata:
American journal of physiology. Lung cellular and molecular physiology
fascicolo: 1, volume: 16, anno: 1997,
pagine: 124 - 131
SICI:
1040-0605(1997)16:1<124:AACEOA>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASOACTIVE-INTESTINAL-PEPTIDE; EXHALED AIR; GUINEA-PIGS; IN-VITRO; SYNTHASE; INDUCTION; MACROPHAGES; EPITHELIUM; MODULATION; HUMANS;
Keywords:
NITRIC OXIDE SYNTHASE; ASTHMA; BRONCHOCONSTRICTION; RESPIRATORY RESISTANCE; GUINEA PIG;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
S. Mehta et al., "ACUTE AND CHRONIC EFFECTS OF ALLERGIC AIRWAY INFLAMMATION ON PULMONARY NITRIC-OXIDE PRODUCTION", American journal of physiology. Lung cellular and molecular physiology, 16(1), 1997, pp. 124-131

Abstract

Nitric oxide (NO) is thought to be an important modulator of airway function in normal and inflamed airways. We investigated the acute and chronic effects of induced allergic airway inflammation on NO levels in mixed expired gas and NO synthase (NOS) expression in guinea pigs and the relationship between airway responses and NO production. Airway inflammation was induced by repeated aerosolized antigen exposure, andits presence was confirmed by bronchoalveolar lavage. Acute antigen exposure in sensitized animals produced a fivefold increase in respiratory resistance over baseline that was associated with a cotemporal increase in expired NO (17 +/- 1 to 56 +/- 8 parts per billion, P < 0.01). A continuous subcutaneous infusion of nitro-L-arginine methyl ester (L-NAME), a competitive inhibitor of NOS, markedly decreased expired NO (P < 0.01) and resulted in a significantly greater rise in resistance following antigen challenge (660 +/- 60 vs. 497 +/- 42% of baseline in non-L-NAME-treated animals, P < 0.05). These data support the hypothesis that endogenous pulmonary NO production, as reflected by expiredNO, has an important homeostatic role in acute allergic bronchoconstriction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 12:07:23