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Titolo:
DISTRIBUTION OF INSULIN-LIKE GROWTH FACTOR-I RECEPTOR MESSENGER-RNA IN RAT-BRAIN - REGULATION IN THE HYPOTHALAMONEUROHYPOPHYSEAL SYSTEM
Autore:
AGUADO F; RODRIGO J; CACICEDO L; MELLSTROM B;
Indirizzi:
CSIC,INST CAJAL,C DR ARCE 37 E-28002 MADRID SPAIN CSIC,INST CAJAL E-28002 MADRID SPAIN HOSP RAMON Y CAJAL,SERV ENDOCRINOL E-28034 MADRID SPAIN
Titolo Testata:
Journal of molecular endocrinology
fascicolo: 2, volume: 11, anno: 1993,
pagine: 231 - 239
SICI:
0952-5041(1993)11:2<231:DOIGFR>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; MESSENGER-RNA; INSITU HYBRIDIZATION; BINDING-SITES; SUPRAOPTIC NUCLEUS; PITUITARY-GLAND; PARS TUBERALIS; ADULT-RAT; C-FOS; EXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
F. Aguado et al., "DISTRIBUTION OF INSULIN-LIKE GROWTH FACTOR-I RECEPTOR MESSENGER-RNA IN RAT-BRAIN - REGULATION IN THE HYPOTHALAMONEUROHYPOPHYSEAL SYSTEM", Journal of molecular endocrinology, 11(2), 1993, pp. 231-239

Abstract

The distribution and regulation of mRNA for the IGF-I receptor (IGF-I-R) in the adult rat brain were studied by in-situ hybridization with a S-35-labelled cRNA probe. The pituitary gland showed a strong hybridization signal in the pars tuberalis (the surface of the median eminence), pars distalis and pars intermedia. Within the brain, a strong hybridization signal was found in the circumventricular organs, olfactorybulb, hippocampus, cerebellum and hypothalamus. IGF-I-R mRNA was consistently found in cell bodies of the hypothalamo-neurohypophysial system. Six days of intermittent salt-loading resulted in an increase in IGF-I-R gene expression in the supraoptic nucleus. The increase in IGF-I-R mRNA was accompanied by a high expression of c-Fos immunoreactivity in the same cells. The presence and regulation of IGF-I-R mRNA in the hypothalamus suggest that IGF-I may affect the local plasticity or modulation of activated magnocellular neurones by an autocrine or paracrine action through specific receptors in the hypothalamoneurohypophysial system.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 07:18:35