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Titolo:
NEUROTRANSMITTER REGULATION OF SOMATOSTATIN SECRETION BY FETAL-RAT CEREBRAL CORTICAL-CELLS IN CULTURE
Autore:
DELOSFRAILES MT; CACICEDO L; LORENZO MJ; TOLON RM; FERNANDEZ G; FRANCO FS;
Indirizzi:
HOSP RAMON Y CAJAL,SERV ENDOCRINOL,CARRETERA COLMENAR KM 9 E-28034 MADRID SPAIN HOSP RAMON Y CAJAL,SERV ENDOCRINOL,CARRETERA COLMENAR KM 9 E-28034 MADRID SPAIN CNIC,INST CARLOS 3 MADRID SPAIN
Titolo Testata:
Journal of endocrinological investigation
fascicolo: 9, volume: 16, anno: 1993,
pagine: 661 - 668
SICI:
0391-4097(1993)16:9<661:NROSSB>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
THYROTROPIN-RELEASING-HORMONE; GAMMA-AMINOBUTYRIC ACID; GROWTH-HORMONE; IMMUNOREACTIVE SOMATOSTATIN; HYPOTHALAMIC FRAGMENTS; BRAIN-CELLS; ACETYLCHOLINE; NEURONS; CORTEX; INHIBITION;
Keywords:
NEUROTRANSMITTERS; SOMATOSTATIN; FETAL CULTURED CEREBRAL CORTICAL NEURONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
54
Recensione:
Indirizzi per estratti:
Citazione:
M.T. Delosfrailes et al., "NEUROTRANSMITTER REGULATION OF SOMATOSTATIN SECRETION BY FETAL-RAT CEREBRAL CORTICAL-CELLS IN CULTURE", Journal of endocrinological investigation, 16(9), 1993, pp. 661-668

Abstract

Extensive studies exploring the regulation of hypothalamic somatostatin GHRIH release have been reported, but the factors regulating GHRIH release in the cerebral cortex have not been well defined. We have studied the effects of central neurotransmitters on GHRIH secretion by cultured fetal rat cerebral cortical cells and on intracellular GHRIH levels. Cells maintained in vitro for 15-20 days were incubated with dopamine (DA), acetylcholine (ACh), gamma-aminobutyric acid (GABA), norepinephrine (NE), serotonin (SE) or histamine (His) (10(-11) M to 10(3) M) for 30 minutes. Following incubation, immunoreactive GHRIH was measured by RIA in cell extracts and incubation media. DA increased intracellular GHRIH content but have no effect on GHRIH in the media. Both media and intracellular GHRIH content were significantly reduced by GABA and SE. The effect of NE was stimulatory at low (10(-9) M) and inhibitory at high (10(-5) M to 10(-3) M) concentrations. ACh was found to increase media GHRIH and to decrease intracellular GHRIH content; 30 min exposure to His did not significantly modify either media or intracellular GHRH. Our findings with fetal rat cerebral cortical cells in culture demonstrate that endogenous neurotransmitters do have the capacity to directly influence GHRIH regulation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 05:28:44