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Titolo:
SIDE-EFFECTS OF THERAPEUTICS IN REPRODUCT IVE MEDICINE - THE EXAMPLE OF DES IN-UTERO EXPOSURE
Autore:
EPELBOIN S; BULWA S;
Indirizzi:
HOP ST VINCENT DE PAUL,CTR MED REPROD,SERV PR JACQUES CHAVINIE,82 AVEDENFERT ROCHEREAU F-75014 PARIS FRANCE
Titolo Testata:
Contraception fertilite sexualite
fascicolo: 9, volume: 21, anno: 1993,
pagine: 658 - 672
SICI:
1165-1083(1993)21:9<658:SOTIRI>2.0.ZU;2-P
Fonte:
ISI
Lingua:
FRE
Keywords:
SIDE EFFECTS OF THERAPIES; REPRODUCTIVE MEDICINE; DES IN UTERO EXPOSURE; ASSISTED PROCREATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
NO
Recensione:
Indirizzi per estratti:
Citazione:
S. Epelboin e S. Bulwa, "SIDE-EFFECTS OF THERAPEUTICS IN REPRODUCT IVE MEDICINE - THE EXAMPLE OF DES IN-UTERO EXPOSURE", Contraception fertilite sexualite, 21(9), 1993, pp. 658-672

Abstract

In the 1940's, diethylstilboestrol (DES) is one of the first hormonaltherapeutics which was prescribed to many pregnant women by a lot of gynecologists. Until 1970, the indications of this therapy was enlarged, before carcinological and reproductives consequences leaded to forbid obstetrical indications of DES (in France, in 1977 only). In France, 80 000 girls and 80 000 boys are suspected to have been exposed. As far as girls are concerned, the studies estimate between 23 % and 36 %the rate of infertility. These studies show also an increased incidence of ectopic pregnancy, spontaneous abortions, and premature delivery. The association between various factors of infertility, and typical uterine abnormalities leads to specific therapeutical indications, mostly in assisted procreations. The history of DES points out prescriptions of a therapeutic without proofs of its efficiency, the silence of pharmaceutical laboratories which did not take into consideration Dieckman's evaluation, and the difficulties for physicians in affording information. Nevertheless, the last patients exposed will be 40 years old in 2016 in France. The other hormonal therapeutics which were discovered gave in turn rise hope for enhancing the fertility and providing from miscarriage. Over the examples such as Des are not still resolvedquestions that patients and physicians ask concerning the lack of adverse effects of a therapy on the foetus, when its clinical efficiency on the pregnancy is supposed to be proved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/10/20 alle ore 07:20:15