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Titolo:
INVOLVEMENT OF THE SEROTONERGIC SYSTEM IN THE HYPOACTIVE AND ANTINOCICEPTIVE EFFECTS OF NICOTINE IN MICE
Autore:
DAMAJ MI; GLENNON RA; MARTIN BR;
Indirizzi:
VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,DEPT PHARMACOL & TOXICOLRICHMOND VA 23298 VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,DEPT PHARMACOL & TOXICOLRICHMOND VA 23298 VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,DEPT MED CHEM RICHMOND VA 23298
Titolo Testata:
Brain research bulletin
fascicolo: 2, volume: 33, anno: 1994,
pagine: 199 - 203
SICI:
0361-9230(1994)33:2<199:IOTSSI>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
TAIL-FLICK; 5-HYDROXYTRYPTAMINE; BRAIN; MORPHINE; NEURONS; RATS; AGONISTS; MICRODIALYSIS; ANTAGONISTS; WITHDRAWAL;
Keywords:
NICOTINE; SEROTONIN; ANTINOCICEPTION; 5-HT1A RECEPTOR; MICE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
M.I. Damaj et al., "INVOLVEMENT OF THE SEROTONERGIC SYSTEM IN THE HYPOACTIVE AND ANTINOCICEPTIVE EFFECTS OF NICOTINE IN MICE", Brain research bulletin, 33(2), 1994, pp. 199-203

Abstract

Pretreatment with the 5-HT2 antagonist ketanserin and the 5-HT1A/2 antagonist spiperone did not reduce nicotine-induced hypomotility in mice, nor did MDL 7222, a selective 5-HT3 antagonist. In addition, 8-OH-DPAT and buspirone, 5-HT1A agonists, had no significant effects on nicotine-induced hypomotility. However, 8-OH-DPAT and buspirone did reducethe antinociceptive effects of nicotine in a dose-dependent manner. 8-OH-DPAT blockade af this nicotine effect was reversed by spiperone, a5-HT1A/2 antagonist. Nicotine's ED(50) was increased from 1.00 mg/kg (0.90-1.68) to 2.00 mg/kg (1.6-2.55) and 2.66 (1.7-3.51) by buspirone and 8-OH-DPAT, respectively. Ketanserin, spiperone and MDL 7222 had nosignificant effect on nicotine-induced antinociception. The present data suggest an important role of 5-HT1A receptors in the modulation ofantinociceptive actions of nicotine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 22:58:30