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Titolo:
FIBERS IMMUNOREACTIVE FOR NERVE GROWTH-FACTOR RECEPTOR IN ADULT-RAT CORTEX AND HIPPOCAMPUS MIMIC THE INNERVATION PATTERN OF ACHE-POSITIVE FIBERS
Autore:
PETERSON GM; GINN SR; LANFORD GW;
Indirizzi:
E CAROLINA UNIV,SCH MED,DEPT ANAT & CELL BIOL GREENVILLE NC 27858
Titolo Testata:
Brain research bulletin
fascicolo: 2, volume: 33, anno: 1994,
pagine: 129 - 136
SICI:
0361-9230(1994)33:2<129:FIFNGR>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
FIMBRIA-FORNIX TRANSECTION; RETROGRADE AXONAL-TRANSPORT; HUMAN BASAL FOREBRAIN; FACTOR NGF RECEPTOR; CHOLINE-ACETYLTRANSFERASE; MESSENGER-RNA; MONOCLONAL-ANTIBODY; NUCLEUS BASALIS; IMMUNOHISTOCHEMICAL LOCALIZATION; NEUROTROPHIC FACTOR;
Keywords:
SEPTUM; HIPPOCAMPUS; CORTEX; NGF RECEPTOR; ACETYLCHOLINESTERASE; CHOLINERGIC NEURONS; IMMUNOCYTOCHEMISTRY; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
62
Recensione:
Indirizzi per estratti:
Citazione:
G.M. Peterson et al., "FIBERS IMMUNOREACTIVE FOR NERVE GROWTH-FACTOR RECEPTOR IN ADULT-RAT CORTEX AND HIPPOCAMPUS MIMIC THE INNERVATION PATTERN OF ACHE-POSITIVE FIBERS", Brain research bulletin, 33(2), 1994, pp. 129-136

Abstract

Numerous reports have indicated that nerve growth factor (NGF) exertsneurotrophic effects on the cholinergic neurons of the basal forebrain. Receptors for NGF (NGFR) have been demonstrated on cholinergic perikarya in the medial septum, diagonal band of Broca, and basal nucleus of Meynert. These neurons provide the major cholinergic innervation tothe cerebral cortex and hippocampus, and previous studies have shown that their terminal plexuses also possess NGFR. However, these studieshave shown only isolated examples of immunoreactive fibers. In the present paper we confirm and extend the observation of the presence of NGFR immunoreactivity in the hippocampus and cortex of adult rat by showing the entire plexus and demonstrating that the plexus is strikinglysimilar to the pattern of cholinergic innervation. Fibers stained foracetylcholinesterase (AChE) and NGFR immunoreactivity were found in all layers of the parietal cortex. Within the hippocampus, fibers were observed in all regions, but were most dense in the strata oriens, pyramidale, and radiatum of hippocampal subfields CA1 and CA3. Particularly intense staining was found throughout the dentate gyrus. Partial transections of the fimbria-fornix, which disrupt fibers projecting fromthe medial septum to the hippocampus, concomitantly abolish the innervation pattern of both NGFR and AChE. These results provide additionalevidence that NGFR are associated with septohippocampal and basocortical cholinergic fibers.

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Documento generato il 27/01/20 alle ore 16:54:19