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Titolo:
EFFECT OF HIGH-PROTEIN FEED SUPPLEMENTS ON CONCENTRATIONS OF GROWTH-HORMONE (GH), INSULIN-LIKE GROWTH FACTOR-I (IGF-I) AND IGF-BINDING PROTEIN-3 IN PLASMA AND ON THE AMOUNTS OF GH AND MESSENGER-RNA FOR GH IN THE PITUITARY-GLANDS OF ADULT RAMS
Autore:
CLARKE IJ; FLETCHER TP; POMARES CC; HOLMES JHG; DUNSHEA F; THOMAS GB; TILBROOK AJ; WALTON PE; GALLOWAY DB;
Indirizzi:
PRINCE HENRYS INST MED RES,POB 152 CLAYTON VIC 3168 AUSTRALIA UNIV MELBOURNE,DEPT AGR PARKVILLE VIC 3052 AUSTRALIA UNIV MELBOURNE,DEPT VET SCI PARKVILLE VIC 3052 AUSTRALIA CRC TISSUE GROWTH & REPAIR ADELAIDE SA 5000 AUSTRALIA VICTORIAN INST ANIM SCI WERRIBEE VIC 3030 AUSTRALIA
Titolo Testata:
Journal of Endocrinology
fascicolo: 3, volume: 138, anno: 1993,
pagine: 421 - 427
SICI:
0022-0795(1993)138:3<421:EOHFSO>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
RIBONUCLEIC-ACID LEVELS; GONADOTROPIN SUBUNITS; METABOLIC INTERFACES; OVARIECTOMIZED EWES; NUTRITIONAL-STATUS; YOUNG STEERS; DAIRY-COWS; SECRETION; RAT; PROLACTIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
53
Recensione:
Indirizzi per estratti:
Citazione:
I.J. Clarke et al., "EFFECT OF HIGH-PROTEIN FEED SUPPLEMENTS ON CONCENTRATIONS OF GROWTH-HORMONE (GH), INSULIN-LIKE GROWTH FACTOR-I (IGF-I) AND IGF-BINDING PROTEIN-3 IN PLASMA AND ON THE AMOUNTS OF GH AND MESSENGER-RNA FOR GH IN THE PITUITARY-GLANDS OF ADULT RAMS", Journal of Endocrinology, 138(3), 1993, pp. 421-427

Abstract

Three groups of mature rams were maintained on diets of hay, hay + 2%lupin or hay + 2% cowpea for 11 weeks. Serial blood samples were taken at 15-min intervals for 12 h for the determination of GH and IGF-I content by radioimmunoassay and for IGF binding protein-3 (IGFBP-3) levels by Western blotting. The rams were killed after 77 days of supplementary feeding and their pituitary glands analysed for content of GH and GH mRNA. Mean plasma GH and baseline GH levels were significantly (P<0.01) decreased in the rams fed lupin and cowpea compared with controls fed hay and GH pulse amplitude was significantly (P<0.001) decreased in the group fed the cowpea diet. The frequency of GH pulses was not significantly altered by either treatment. Plasma concentrations of IGF-I were elevated in rams fed lupin (P<0.001) or cowpea (P<0.05). IGFBP-3 levels were not significantly (P>0.05) altered by either treatment. There were no significant differences in pituitary content of GH mRNA but pituitary content of GH was increased in rams fed lupin (P<0.05) and cowpea (P=0.07). In conclusion, a high-protein diet decreases plasma GH levels and increases IGF-I without changing plasma IGFBP-3 levels in rams. Thus ongoing synthesis of GH, as indicated by the mRNA levels, may cause a build up of GH stores in the pituitary gland.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 08:50:57