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Titolo:
INTRAVENOUS BENZTROPINE AND PROPRANOLOL CHALLENGES IN TARDIVE AKATHISIA
Autore:
SACHDEV P; LONERAGAN C;
Indirizzi:
PRINCE HENRY HOSP,INST NEUROPSYCHIAT,POB 233 MATRAVILLE NSW 2036 AUSTRALIA PRINCE HENRY HOSP,INST NEUROPSYCHIAT SYDNEY AUSTRALIA
Titolo Testata:
Psychopharmacology
fascicolo: 1, volume: 113, anno: 1993,
pagine: 119 - 122
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUROLEPTIC-INDUCED AKATHISIA; DYSKINESIA;
Keywords:
TARDIVE AKATHISIA; BENZTROPINE; PROPRANOLOL; NEUROLEPTIC DRUGS; ACETYLCHOLINE; BETA-ADRENERGIC ANTAGONIST;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
P. Sachdev e C. Loneragan, "INTRAVENOUS BENZTROPINE AND PROPRANOLOL CHALLENGES IN TARDIVE AKATHISIA", Psychopharmacology, 113(1), 1993, pp. 119-122

Abstract

We challenged five patients suffering from tardive akathisia (TA) with intravenous benztropine (2 mg), propranolol (1 mg) and placebo (saline) using a random, double-blind cross-over design to examine the effects of the drugs on the subjective, objective and global manifestations of neuroleptic-induced akathisia. Benztropine produced a marginally significant, and propranolol a significant improvement in the overall manifestations of the disorder. The patients demonstrated a considerable placebo effect and marked variation in their responses to the drugs. The implications of these findings for the pathophysiology of TA in relation to acute akathisia and tardive dyskinesia are discussed.

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Documento generato il 21/01/20 alle ore 07:00:19