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Titolo:
RAPID MEASUREMENT OF REGIONAL CEREBRAL BLOOD-FLOW IN THE BABOON USINGO-15-LABELED WATER AND DYNAMIC POSITRON EMISSION TOMOGRAPHY
Autore:
PINARD E; MAZOYER B; VERREY B; PAPPATA S; CROUZEL C;
Indirizzi:
CEA,SERV HOSP FREDERIC JOLIOT F-91406 ORSAY FRANCE CEA,SERV HOSP FREDERIC JOLIOT F-91406 ORSAY FRANCE CEA,DEPT RECH IMAGERIE PHYSIOL PHARMACOL,INSERM,U344 F-91406 ORSAY FRANCE CHU LARIBOISIERE ST LOUIS,RECH CEREBROVASC,CNRS,UA 641 PARIS FRANCE CHU BICHAT,HOP ROBERT DEBRE PARIS FRANCE
Titolo Testata:
Medical & biological engineering & computing
fascicolo: 5, volume: 31, anno: 1993,
pagine: 495 - 502
SICI:
0140-0118(1993)31:5<495:RMORCB>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
QUANTITATIVE MEASUREMENT; INTRAVENOUS (H2O)-O-15; PARTITION-COEFFICIENT; COMPUTED-TOMOGRAPHY; ERROR ANALYSIS; INPUT FUNCTION; BRAIN; TRACER; O-15-WATER; VALIDATION;
Keywords:
BABOON; BOLUS INJECTION; CO2 REACTIVITY; O-15-LABELED WATER; POSITRON EMISSION TOMOGRAPHY; REGIONAL CEREBRAL BLOOD FLOW;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
E. Pinard et al., "RAPID MEASUREMENT OF REGIONAL CEREBRAL BLOOD-FLOW IN THE BABOON USINGO-15-LABELED WATER AND DYNAMIC POSITRON EMISSION TOMOGRAPHY", Medical & biological engineering & computing, 31(5), 1993, pp. 495-502

Abstract

The sensitivity and reproducibility of rapid measurements of regionalcerebral flow (rCBF) using a bolus injection of (H2O)-O-15 and dynamic positron emission tomography (PET) were investigated in anaesthetised baboons. The cerebrovascular reactivity to changes in arterial pCO2 was used as an experimental support. PET data were acquired over 4 minfollowing a single bolus intravenous injection of (H2O)-O-15, while arterial blood was withdrawn for continuous activity counting. Images were reconstructed with a dynamic sequence of 45 x 2s + 15 x 10s, including a correction for decay. Regional values of CBF were derived from non-linear least-squares fits of the time activity curves using a four-parameter two-compartment model. The results obtained with a four-parameter fitting method were compared with those obtained with two otherrapid estimation methods, first fitting two parameters only, CBF and partition coefficient (p), and secondly autoradiography (with p fixed at 0.95 ml brain ml blood-1). Twelve regions of interest were analysed. The values for the basal CBF obtained from 13 measurements in two baboons were close to published values obtained with other techniques. Reproducibility checks showed a mean variation of 9.7 per cent. The CBFmeasurements performed in hypercapnic conditions gave results similarto published data in other animal species, showing a 4.5 +/- 0.9 per cent increase in CBF per mm Hg paCO2. The results obtained with the three estimation techniques were closely correlated. The dynamic bolus (H2O)-O-15 method appeared to be suitable for high blood flow measurements.

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Documento generato il 03/12/20 alle ore 15:48:15