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Titolo:
IN-SITU HYBRIDIZATION OF HIV-1 RNA IN RETINAL VASCULAR WALL
Autore:
REUX I; FILLET AM; FOURNIER JG; AGUT H; GENTILINI M; LEHOANG P; HAUW JJ;
Indirizzi:
GRP HOSP PITIE SALPETRIERE,NEUROPATHOL RAYMOND ESCOUROLLE LAB,83 BLVDHOP F-75634 PARIS 13 FRANCE ASSOC CLAUDE BERNARD,INSERM,U360,NEUROPATHOL RAYMOND ESCOUROLLE LAB PARIS FRANCE HOP ST VINCENT DE PAUL,INSERM,U43 F-75674 PARIS 14 FRANCE GRP HOSP PITIE SALPETRIERE,BACTERIOL VIROL LAB F-75634 PARIS 13 FRANCE GRP HOSP PITIE SALPETRIERE,ASSOC CLAUDE BERNARD,CERVI,SERV MALAD INFECT & PARASITAIRES F-75634 PARIS 13 FRANCE GRP HOSP PITIE SALPETRIERE,SERV OPHTALMOL F-75634 PARIS 13 FRANCE
Titolo Testata:
The American journal of pathology
fascicolo: 5, volume: 143, anno: 1993,
pagine: 1275 - 1279
SICI:
0002-9440(1993)143:5<1275:IHOHRI>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; IMMUNE-DEFICIENCY SYNDROME; INFECTION; AIDS; CELLS; LOCALIZATION; INVOLVEMENT;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
I. Reux et al., "IN-SITU HYBRIDIZATION OF HIV-1 RNA IN RETINAL VASCULAR WALL", The American journal of pathology, 143(5), 1993, pp. 1275-1279

Abstract

In situ hybridization of human immunodeficiency virus-1 (HIV-1) has been performed on eight eyes from eight distinct acquired immune deficiency syndrome patients (three cases bad a normal fundus examination and five presented with cytomegalovirus retinitis). The eyes were removed at autopsy and frozen immediately. Contiguous 10-mu cryostat sections were obtained and tested with a HIV probe labeled by nick-translation with [S-35]-ATP. HIV-1 RNA was detected in the retina of two acquired immune deficiency syndrome patients. The first positive case presented with typical ophthalmological and histopathological cytomegalovirusretinitis, the second one was not related to cytomegalovirus, according to clinical or histopathological classical criterias. HIV-1 was localized in retinal vascular walls. This shows that there is an active replication of HIV in retina of some acquired immune deficiency syndrome patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 10:26:22