Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
HISTONE VARIANTS, H(1) SUBTYPES AND OTHER CHROMATIN PROTEINS AS BIOMARKERS OF AGE AND CALORIC RESTRICTION IN RATS
Autore:
PIPKIN JL; HINSON WG; LYNCOOK LE; FEUERS RJ; BURNS ER; HART R; DUFFY PF; CASCIANO DA;
Indirizzi:
US FDA,NATL CTR TOXICOL RES,DEPT HLTH & HUMAN SERV,DIV GENET TOXICOL JEFFERSON AR 72079 UNIV ARKANSAS MED SCI HOSP,DEPT ANAT LITTLE ROCK AR 72205
Titolo Testata:
Age
fascicolo: 3, volume: 16, anno: 1993,
pagine: 97 - 103
SICI:
0161-9152(1993)16:3<97:HVHSAO>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOBILITY-GROUP PROTEINS; DRUG-METABOLIZING ENZYMES; CELL-CYCLE; DIETARY RESTRICTION; FISCHER-344 RAT; FREE UBIQUITIN; PHOSPHORYLATION; LIVER; MOUSE; SPERMATOGENESIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
59
Recensione:
Indirizzi per estratti:
Citazione:
J.L. Pipkin et al., "HISTONE VARIANTS, H(1) SUBTYPES AND OTHER CHROMATIN PROTEINS AS BIOMARKERS OF AGE AND CALORIC RESTRICTION IN RATS", Age, 16(3), 1993, pp. 97-103

Abstract

The synthesis and phosphorylation levels of basic chromatin proteins from cell cycle phases of dividing bone marrow cells in Fischer 344 rats were investigated by gel electrophoresis. Two groups of rats, youngad libitum (Y/A 3 mo.) and old ad libitum (O/AL 28 mo.), had free access to rat chow, and a third group of old rats was maintained on a calorie-restricted intake (O/CR 28 mo.). Histone H-1 subtypes a, b and c from combined S+G2 phase revealed highest amounts of [H-3] lysine incorporation in Y/AL, lowest in O/AL, and intermediate levels in O/CR animals, while subtypes e and I-degrees were highest in O/AL, lowest in Y/AL, and mid level in O/CR. The P-32-orthophosphate incorporation of these subtypes followed a parallel scenario as with lysine. Histone H-4variants from S phase demonstrated the highest levels of lysine labeling in O/AL, lowest in Y/AL and intermediate levels in O/CR. The H-1 variants were similar in synthesis patterns to H-4 variants but less dramatic. Minor histone variants M2, M3 and M4 manifested most synthesisin O/AL, least in Y/AL and mid levels in O/CR. Conversely, M1 synthesis was high in Y/AL, low in O/AL and modest in O/CR. Ubiquitin followed a similar pattern in lysine labeling to M1 and A24 which was inversely proportional to ubiquitin. The metabolic activity of these basic proteins in O/CR exemplifies a condition characteristic of Y/AL animals modulated by age and diet dependent factors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 11:31:56