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Titolo:
OCTREOTIDE AND CHOLECYSTOKININ ANTAGONIST REDUCE EDEMA IN OBSTRUCTION-INDUCED ACUTE-PANCREATITIS
Autore:
TORIUMI Y; SAMUEL I; WILCOCKSON DP; TURKELSON CM; SOLOMON TE; JOEHL RJ;
Indirizzi:
VET AFFAIRS LAKESIDE MED CTR,SURG SERV 112,333 E HURON ST CHICAGO IL 60611 VET AFFAIRS LAKESIDE MED CTR,SURG SERV 112,333 E HURON ST CHICAGO IL 60611 VET AFFAIRS LAKESIDE MED CTR,RES SERV CHICAGO IL 60611 NORTHWESTERN UNIV,SCH MED,DEPT SURG CHICAGO IL 60611
Titolo Testata:
The Journal of laboratory and clinical medicine
fascicolo: 4, volume: 122, anno: 1993,
pagine: 450 - 454
SICI:
0022-2143(1993)122:4<450:OACARE>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
SOMATOSTATIN ANALOG; DUCT OBSTRUCTION; RAT; SECRETION; BILE; EXOCRINE; RELEASE; PREVENTION; L-364,718; FOOD;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
Y. Toriumi et al., "OCTREOTIDE AND CHOLECYSTOKININ ANTAGONIST REDUCE EDEMA IN OBSTRUCTION-INDUCED ACUTE-PANCREATITIS", The Journal of laboratory and clinical medicine, 122(4), 1993, pp. 450-454

Abstract

Obstruction-induced acute pancreatitis in rats is associated with increased plasma cholecystokinin (CCK) levels. Duodenal replacement of bile reduces severity of pancreatitis and limits CCK increase. We investigated the role of CCK in the pathogenesis of obstruction-induced acute pancreatitis by pretreating rats with the somatostatin analog octreotide and the CCK antagonist L-364,718. Octreotide inhibits duodenal CCK release, and L-364,718 competitively blocks CCK receptors. We studied 31 rats after (1) sham operation (n = 7), (2) bile and pancreatic duct obstruction (BPDO) (n = 12), (3) BPDO plus octreotide (20 mug/kg IPand then 5 mug/kg/hr IV) (n = 6), and (4) BPDO plus L-364,718 (1 mg/kg (IP)and then 0.25 mg/kg/hr IV) (n = 6). Rats were killed after 18 hours. Pancreas weight, acute pancreatitis histology score, and plasma amylase and CCK levels were determined. Octreotide and L-364,718 limited the increase in pancreas weight. Octreotide also limited the rise inplasma CCK levels. These findings suggest that CCK may play a role inthe pathogenesis of obstruction-induced acute pancreatitis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 00:53:54