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Titolo:
POSTISCHEMIC DETERIORATION OF SARCOPLASMIC-RETICULUM - WARM VERSUS COLD BLOOD CARDIOPLEGIA
Autore:
LIU XK; ENGELMAN RM; WEI ZJ; MAULIK N; ROUSOU JA; FLACK JE; DEATON DW; DAS DK;
Indirizzi:
BAYSTATE MED CTR,DEPT SURG,DIV CARDIAC SURG,759 CHESTNUT ST SPRINGFIELD MA 01107 BAYSTATE MED CTR,DEPT CARDIAC SURG SPRINGFIELD MA 01107 UNIV CONNECTICUT,SCH MED,DEPT SURG,SURG RES CTR,DIV CARDIOVASC FARMINGTON CT 06032
Titolo Testata:
The Annals of thoracic surgery
fascicolo: 5, volume: 56, anno: 1993,
pagine: 1154 - 1159
SICI:
0003-4975(1993)56:5<1154:PDOS-W>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
STUNNED MYOCARDIUM; TEMPERATURE; CALCIUM; RESERVE; SYSTEM; ARREST;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
X.K. Liu et al., "POSTISCHEMIC DETERIORATION OF SARCOPLASMIC-RETICULUM - WARM VERSUS COLD BLOOD CARDIOPLEGIA", The Annals of thoracic surgery, 56(5), 1993, pp. 1154-1159

Abstract

Impaired cardiac sarcoplasmic reticulum (SR) function, as evidenced by reduced SR Ca2+ uptake rate and decreased SR Ca2+-adenosine triphosphatase activity, has been found in postischemic ''stunned'' myocardiumand in hearts subjected to hypothermic arrest. In this study, we compared the effects of retrograde continuous coronary sinus warm blood cardioplegia (WBC) and retrograde intermittent cold blood cardioplegia (CBC) on cardiac SR function and postischemic ventricular functional recovery in pig hearts. Twelve in situ isolated pig hearts supported by cardiopulmonary bypass were subjected to 120 minutes of cardioplegic arrest with either WBC (37-degrees-C) or CBC (6-degrees to 10-degrees-C), followed by 60 minutes of 37-degrees reperfusion. Left ventricular global contractile function and coronary blood flow were measured before arrest and during reperfusion. Cardiac SR was isolated from left ventricular biopsy specimens, and Ca-45(2+) uptake by SR and SR Ca2+-adenosine triphosphatase activity were determined. The recovery of left ventricular global contractile function as indicated by the maximum of the first derivative of left ventricular pressure was significantly improved in the WBC group compared with that of the CBC group (70% versus 46%; p < 0.05). The SR Ca2+-adenosine triphosphatase activity was better preserved after 60 minutes reperfusion in WBC compared with CBC (0.31 +/- 0.02 versus 0.20 +/- 0.03 muM Pi/min/mg protein, p < 0.05), and the recovery of SR Ca2+ uptake was significantly improved by WBC compared with CBC (1.15 +/- 0.12 versus 0.83 +/- 0.04 muM Ca2+/min/mg protein; p < 0.05). These results indicate that the superiority of continuous WBC over intermittent CBC in promoting functional recovery may be related to its ability to improve postischemic SR function, which presumably plays a crucial role in regulating cellular Ca2+ homeostasis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 06:00:23