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Titolo:
SIMPLE DIAGNOSTIC STATISTICAL TESTS OF MODELS FOR DNA SUBSTITUTION
Autore:
GOLDMAN N;
Indirizzi:
NATL INST MED RES,MATH BIOL LAB,RIDGEWAY,MILL HILL LONDON NW7 1AA ENGLAND UNIV CAMBRIDGE,MUSEUM ZOOL CAMBRIDGE CAMBS ENGLAND
Titolo Testata:
Journal of molecular evolution
fascicolo: 6, volume: 37, anno: 1993,
pagine: 650 - 661
SICI:
0022-2844(1993)37:6<650:SDSTOM>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAXIMUM-LIKELIHOOD APPROACH; EVOLUTIONARY TREES; MOLECULAR EVOLUTION; LINEAR INVARIANTS; SEQUENCE DATA; NUCLEIC-ACID; MANS PLACE; HOMINOIDEA; RATES; PHYLOGENY;
Keywords:
PHYLOGENETIC INFERENCE; EVOLUTIONARY MODELS; STATISTICAL TESTING; HYPOTHESIS TESTING; CONSTANT SITES; INVARIANT SITES; SELECTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
N. Goldman, "SIMPLE DIAGNOSTIC STATISTICAL TESTS OF MODELS FOR DNA SUBSTITUTION", Journal of molecular evolution, 37(6), 1993, pp. 650-661

Abstract

The accuracy of models for DNA substitution used in phylogenetic analyses is becoming more important with the increasing availability and analysis of molecular sequence data. It is natural to look for ways of improving these models, and to do this in a planned manner it is useful to be able to identify features of sequences that may not be described adequately. In this paper, I describe three statistics which may give useful diagnostic information on departures from models' predictions. The statistical distributions of these statistics are discussed andsimple significance tests are derived. These tests are based on the (estimated) phylogeny of the sequences and so have the advantage of using the information contained in this tree. Examples are given of the application of the new tests to Markov chain models describing the evolution of primate pseudogene sequences and small-subunit RNA sequences.

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Documento generato il 18/09/20 alle ore 09:16:14