Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
TISSUE-SPECIFIC REGULATION OF IL-6 PRODUCTION BY IL-4 - DIFFERENTIAL-EFFECTS OF IL-4 ON NUCLEAR FACTOR-KAPPA-B ACTIVITY IN MONOCYTES AND FIBROBLASTS
Autore:
DONNELLY RP; CROFFORD LJ; FREEMAN SL; BURAS J; REMMERS E; WILDER RL; FENTON MJ;
Indirizzi:
US FDA,CTR BIOL EVALUAT & RES,DIV CYTOKINE BIOL,BLDG 29A,ROOM 2B-11,8800 ROCKVILLE PIKE BETHESDA MD 20892 NIAMSD,ARTHRITIS & RHEUMAT BRANCH BETHESDA MD 20892 BOSTON UNIV,MED CTR,DEPT MED BOSTON MA 02118 BOSTON UNIV,MED CTR,EVANS MEM DEPT CLIN RES BOSTON MA 02118
Titolo Testata:
The Journal of immunology
fascicolo: 10, volume: 151, anno: 1993,
pagine: 5603 - 5612
SICI:
0022-1767(1993)151:10<5603:TROIPB>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; HUMAN RECOMBINANT INTERLEUKIN-4; HEPATOCYTE-STIMULATING FACTOR; GENE-EXPRESSION; ENDOTHELIAL-CELLS; RHEUMATOID-ARTHRITIS; TRANSCRIPTION FACTOR; BLOOD MONOCYTES; FACTOR-ALPHA; HUMAN PROINTERLEUKIN-1-BETA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
65
Recensione:
Indirizzi per estratti:
Citazione:
R.P. Donnelly et al., "TISSUE-SPECIFIC REGULATION OF IL-6 PRODUCTION BY IL-4 - DIFFERENTIAL-EFFECTS OF IL-4 ON NUCLEAR FACTOR-KAPPA-B ACTIVITY IN MONOCYTES AND FIBROBLASTS", The Journal of immunology, 151(10), 1993, pp. 5603-5612

Abstract

IL-4 inhibits production of certain proinflammatory cytokines, including IL-1beta, TNF-alpha, and IL-6, by activated monocytes. Although monocytes are a major source of IL-6, other cell types such as fibroblasts and endothelial cells can also express this cytokine. To determine whether IL-4 inhibits IL-6 expression in non-hemopoietic cells, we investigated the effects of IL-4 on IL-6 production in both primary humanfibroblasts and fibroblast lines. Rheumatoid synovial fibroblasts were evaluated in these studies because, like monocytes, they produce high levels of IL-6 when stimulated with IL-1. Although peripheral blood monocytes did not constitutively express IL-6 mRNA or protein, stimulation with IL-1 or LPS induced de novo IL-6 expression in these cells. In contrast, synovial fibroblasts displayed a significant basal level of IL-6 production, which was markedly increased after stimulation with IL-1. IL-4 suppressed IL-6 expression in monocytes, but did not inhibit IL-6 production in synovial fibroblasts. The inability of IL-4 to suppress IL-6 synthesis in rheumatoid synovial fibroblasts was not caused by a lack of IL-4R and was not unique to these cells because IL-4 also failed to inhibit IL-6 production in normal fibroblast lines derived from other tissues. Inhibition of IL-6 production by IL-4 in monocytes was associated with decreased nuclear NF-kappaB levels. However, IL-4 does not globally suppress the activity of all DNA-binding proteins because IL-4 treatment did not reduce the levels of NF-IL-6 or NF-IL-1betaB in the same cells. Because NF-kappaB activation is required for transcription of many cytokine genes, including IL-6, the ability of IL-4 to suppress NF-kappaB activity in monocytes suggests a potential mechanism by which this molecule may inhibit the expression of multiple cytokines.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 11:07:00