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Titolo:
INFLUENCE OF DIFFERENT STARTING TIME OF UROKINASE THERAPY AFTER ACUTEMYOCARDIAL-INFARCTION ON EFFICACY OF THROMBOLYSIS
Autore:
CHEN ZJ; KOU WR; XU YS; MU RQ; DU M; CHEN CX; HUANG JQ; GUO JX; GE KY; SHI JL; SUN YM; DUAN BX; GONG HH; LI GJ; WANG LM; HUANG YL; FU L; SHEN LH; YANG JS; TONG M; HU XL; LIU RY; CUN ZC; WU XS; CHEN Z; LI TD; GAI LY; LI YQ; LIU ZM; SHI SY; TANG Z; GAO BX; LIU ZX; LI Y; ZHANG JX; ZHAO HY; WANG L; WANG SG; CHI CF; SONG DL; SU ZT; CHEN SX; SHEN ZF; JIA GL; LI LS; JIN L; ZHU WL; NING PY; GAO Y; LU ZF; LI YL; DU XP; JI GL; LIU YN; YU JJ; WANG WB; LI XR; HU ZX; ZHENG ZG; LUO BJ; HUANG DS; LI CY; LU HS; TANG BX; WANG JY; LIU RY; WEI JH; JIANG YS; SUN PL; SHI XY; XIONG JR; DENG CX; ZHAO YJ;
Indirizzi:
FU WAI HOSP,CAMS BEIJING 100037 PEOPLES R CHINA FU WAI HOSP,CAMS BEIJING 100037 PEOPLES R CHINA FU WAI HOSP,PUMC BEIJING 100037 PEOPLES R CHINA BEIJING EMERGENCY MED CTR BEIJING PEOPLES R CHINA CHINESE MED UNIV,AFFILIATED HOSP 1 SHENYANG PEOPLES R CHINA BEIJING MED UNIV,AFFILIATED HOSP 3 BEIJING 100083 PEOPLES R CHINA TIANJIN MED UNIV,GEN HOSP TIANJIN PEOPLES R CHINA NANJING FIRST HOSP NANJING PEOPLES R CHINA HARBIN FIRST HOSP HARBIN PEOPLES R CHINA HARBIN MED COLL,AFFILIATED HOSP 1 HARBIN PEOPLES R CHINA BEIJING FRIENDSHIP HOSP BEIJING PEOPLES R CHINA SHENYANG GEN HOSP SHENYANG PEOPLES R CHINA BEIJING RED CROSS CHAO YANG HOSP BEIJING PEOPLES R CHINA BEIJING AN ZHEN HOSP BEIJING PEOPLES R CHINA BEIJING XUAN WU HOSP BEIJING PEOPLES R CHINA BEIJING JI SHUI TAN HOSP BEIJING PEOPLES R CHINA TONG JI MED UNIV,TONG JI HOSP SHANGHAI PEOPLES R CHINA TIANJIN RAILWAY CENT HOSP TIANJIN PEOPLES R CHINA DALIAN MED UNIV,AFFILIATED HOSP 1 DALIAN PEOPLES R CHINA TIANJIN CHEST HOSP TIANJIN PEOPLES R CHINA FOURTH MIL MED UNIV XIAN PEOPLES R CHINA BEIJING UNION MED COLL HOSP BEIJING 100730 PEOPLES R CHINA BEIJING FU XING HOSP BEIJING PEOPLES R CHINA BEIJING BLDG ENGN GEN HOSP BEIJING PEOPLES R CHINA LANGFANG HOSP LANGFANG PEOPLES R CHINA CHINA JAPAN FRIENDSHIP HOSP BEIJING PEOPLES R CHINA DALIAN MED UNIV,AFFILIATED HOSP 2 DALIAN PEOPLES R CHINA BEIJING POST TELECON GEN HOSP BEIJING PEOPLES R CHINA HENAN MED UNIV,AFFILIATED HOSP 1 ZHENGZHOU PEOPLES R CHINA NAVY GEN HOSP BEIJING PEOPLES R CHINA
Titolo Testata:
Chinese medical journal
fascicolo: 1, volume: 110, anno: 1997,
pagine: 47 - 49
SICI:
0366-6999(1997)110:1<47:IODSTO>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
7
Recensione:
Indirizzi per estratti:
Citazione:
Z.J. Chen et al., "INFLUENCE OF DIFFERENT STARTING TIME OF UROKINASE THERAPY AFTER ACUTEMYOCARDIAL-INFARCTION ON EFFICACY OF THROMBOLYSIS", Chinese medical journal, 110(1), 1997, pp. 47-49

Abstract

Objective To investiagte the influence of different starting time of intravenous urokinase after onset of acute myocardial infarction on the efficacy of thrombolysis. Methods One thousand one hundred and thirty eight cases of acute myocardial infarction admitted in 37 collaborative hospitals were given intravenous urokinase with a standard program. Patency of infarct-related coronary artery was assessed by uniform clinical criteria. Patency rate and 4-week mortality in groups of different starting time of urokinase administration after acute onset were compared. Results According to the starting time of urokinase administration after acute onset, the 1138 cases were divided into 4 groups: 128 cases were within 2 hours (h), 461 within 2-4h, 434 within 4-6h and115 within 6-12h. The patency rates were 71.9%, 70.1%, 63.6% and 40.0%, respectively and 4-week mortalities were 7.0%, 6.5%, 12.2% and 13.9%, respectively in the four groups. The differences of patency rates and 4-week mortalities between the groups within 2 hours and within 2-4hours were not statistically significant, so these two groups were combined into one, i.e. within 4 hours. The patency rate of the group within 4 hours (70.5%) was significantly higher than those of the groupswithin 4-6 hours (P < 0.025) and within 6-12 hours (P < 0.001); the 4-week mortality of the former (6.6%) was obviously lower than those ofthe latter two (all P < 0.01). The patency rate of the group within 4-6 hours was higher (P < 0.001), than that of the group within 6-12 hours but the 4-week mortalities were not statistically different between the two groups. Conclusion Intravenous urokinase starting within 4 hours after onset of acute myocardial infarction is of the best efficacy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/18 alle ore 01:55:06