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Titolo:
LACK OF ASSOCIATION OF THE ANGIOTENSIN-CONVERTING ENZYME GENE POLYMORPHISM WITH ESSENTIAL-HYPERTENSION IN A CHINESE POPULATION
Autore:
CHIANG FT; LAI ZP; CHERN TH; TSENG CD; HSU KL; LO HM; TSENG YZ;
Indirizzi:
NATL TAIWAN UNIV HOSP,DEPT INTERNAL MED,7 CHUNG SHAN S RD TAIPEI 10016 TAIWAN NATL TAIWAN UNIV,COLL MED,DEPT LAB MED TAIPEI 10764 TAIWAN
Titolo Testata:
American journal of hypertension
fascicolo: 2, volume: 10, anno: 1997,
pagine: 197 - 201
SICI:
0895-7061(1997)10:2<197:LOAOTA>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
INSERTION DELETION POLYMORPHISM; LEFT-VENTRICULAR HYPERTROPHY; HIGH BLOOD-PRESSURE; DIPEPTIDYL CARBOXYPEPTIDASE-1; MYOCARDIAL-INFARCTION; LINKAGE;
Keywords:
ANGIOTENSIN CONVERTING ENZYME; ESSENTIAL HYPERTENSION; POLYMORPHISM; PLASMA ANGIOTENSIN CONVERTING ENZYME ACTIVITY; GENETICS; CHINESE; RACE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
F.T. Chiang et al., "LACK OF ASSOCIATION OF THE ANGIOTENSIN-CONVERTING ENZYME GENE POLYMORPHISM WITH ESSENTIAL-HYPERTENSION IN A CHINESE POPULATION", American journal of hypertension, 10(2), 1997, pp. 197-201

Abstract

To examine the association between insertion/deletion (I/D) polymorphism of the angiotensin converting enzyme (ACE) gene and essential hypertension in a Chinese population, a case-control study was conducted using 157 hypertensive and 115 normotensive subjects. The I/D polymorphism of the ACE gene was identified by polymerase chain reaction. Plasma ACE activity was determined using spectrophotometry. The difference of allele frequencies between normotensives and hypertensives was statistically significant (chi(2) = 4.467, P = .035), while the gentotype distribution was not different between normotensive and hypertensive subjects (chi(2) = 3.954, P = .138). Plasma ACE activity was highest inthe DD genotype, followed by the ID genotype, and the lowest in the II genotype (P = .0001 in normotensives and P = .163 in hypertensives, respectively). Thus, we conclude that the ACE gene polymorphism is notassociated with essential hypertension in this Chinese population, but plasma ACE activity is genetically determined in the normotensive Chinese. (C) 1997 American JournaI of Hypertension, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/08/20 alle ore 09:00:54